Research Papers:

Dietary factors and microRNA-binding site polymorphisms in the IL13 gene: risk and prognosis analysis of colorectal cancer

Yanming Yu, Junde Zhou, Chen Gong, Zhiping Long, Jingshen Tian, Lin Zhu, Jing Li, Hongyuan Yu, Fan Wang _ and Yashuang Zhao

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Oncotarget. 2017; 8:47379-47388. https://doi.org/10.18632/oncotarget.17649

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Yanming Yu1,*, Junde Zhou2,*, Chen Gong1, Zhiping Long1, Jingshen Tian1, Lin Zhu1, Jing Li1, Hongyuan Yu1, Fan Wang1 and Yashuang Zhao1

1Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China

2Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, P. R. China

*These authors have contributed equally to this work

Correspondence to:

Fan Wang, email: yifan.701@163.com

Yashuang Zhao, email: zhao_yashuang@263.net

Keywords: dietary factors, miRNA-binding site, polymorphisms, IL13, colorectal cancer

Received: December 20, 2016     Accepted: April 21, 2017     Published: May 07, 2017


Long-term dietary intake influences the structure and activity of microorganisms residing in the human gut. The immune response and gut microbiota have a mutual influence on the risk of colorectal cancer (CRC). This study examines the association of gut microbiota–related dietary factors and polymorphisms in the microRNA-binding site of the interleukin 13 gene (IL13) with the risk and prognosis of CRC. Three polymorphisms (rs847, rs848, and rs1295685) were selected for genotyping in a case–control study (513 cases, 572 controls), and 386 CRC patients were followed up. Two dietary factors closely related with gut microbiota (allium vegetables, overnight meal) were significantly associated with CRC development. Although the three SNPs showed no statistically significant associations with the risk and prognosis of CRC, a significant antagonistic interaction was found between rs848 (G–T) and allium vegetable intake (ORi (odds ratio of interaction), 0.92; 95% CI (confidence interval): 0.86, 0.99; P = 0.03); moreover, significant combined and synergistic interactions were observed for all three SNPs and overnight meal intake. This is the first report of significant combined and interactive effects between dietary factors and polymorphisms in the microRNA binding site of IL13 in CRC and may provide direct guidance on intake of allium vegetable and overnight meals for individuals with specific genetic variants of IL13 to modify their susceptibility to CRC.

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