Oncotarget

Research Papers:

A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china

Jin-Hu Fan, Yu-Qing Zhang, Su-Sheng Shi, Yuan-Jia Chen, Xing-Hua Yuan, Li-Ming Jiang, Shao-Ming Wang, Li Ma, Yu-Tong He, Chang-Yan Feng, Xi-Bin Sun, Qing Liu, Katrina Deloso, Yihebali Chi and You-Lin Qiao _

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Oncotarget. 2017; 8:71699-71708. https://doi.org/10.18632/oncotarget.17599

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Abstract

Jin-Hu Fan1,*, Yu-Qing Zhang1,*, Su-Sheng Shi2, Yuan-Jia Chen3, Xing-Hua Yuan4, Li-Ming Jiang5, Shao-Ming Wang1, Li Ma6, Yu-Tong He7, Chang-Yan Feng8, Xi-Bin Sun9, Qing Liu10, Katrina Deloso11, Yihebali Chi12 and You-Lin Qiao1

1Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

2Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

3Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

4Department of Abdominal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

5Department of Radiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

6Department of Epidemiology, Dalian Medical University

7Hebei Cancer Registry, the Fourth hospital of Hebei medical university

8Department of Nutrition, Chongqing Cancer Hospital & Institute & Cancer Center

9Department of Cancer Epidemiology, Henan Cancer Hospital/Institute

10Department of Cancer Prevention, Sun Yat-sen University Cancer Center

11Division of Biological Sciences, the University of Chicago

12Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College

*These authors have contributed equally to this work

Correspondence to:

You-Lin Qiao, email: [email protected]

Yihebali Chi, email: [email protected]

Keywords: neuroendocrine tumors, digestive system, epidemiology, retrospective study multicenter study

Received: October 20, 2016    Accepted: April 11, 2017    Published: May 03, 2017

ABSTRACT

Background: Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients.

Methods: This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients’ information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared.

Results: The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups.

Conclusions:More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.


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