Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats’ colon via NF-κB pathway

Guanqun Chao; Shuo Zhang

doi:10.18632/oncotarget.17565

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats’ colon via NF-κB pathway

Guanqun Chao and Shuo Zhang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:47175-47183. https://doi.org/10.18632/oncotarget.17565

Metrics: PDF 2323 views | HTML 3515 views | ?

Abstract

Guanqun Chao1 and Shuo Zhang2

1Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China

2Department of Gastroenterology, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China

Correspondence to:

Shuo Zhang, email: [email protected]

Keywords: irritable bowel syndrome, aquaporins, NF-κB

Received: November 04, 2016 Accepted: April 18, 2017 Published: May 02, 2017

ABSTRACT

Objective: Our research was to detect the expression of aquaporins. NF-κB in Irritable bowel syndrome (IBS) rat models’ colon so as to find novel pathogenesisof IBS.

Results: The expression of AQP1, AQP3, and AQP8 of IBS model group was down-regulated while NF-κB p65 was up-regulated comparing with control group (p < 0.05), and the expression of AQP1, AQP3, and AQP8 of inhibitor group was up-regulated while NF-κB p65 was down-regulated comparing with IBS model group (p < 0.05).

Materials and Methods: 18 adult female SD big rats were divided into three groups:the rats in control group were normal rats,the rats in IBS model group and the rats of inhibitor group were injected with the inhibitor of NF-κB (PDTC). Immunohistochemical technique and western blot were performed to detect the expression of AQP1, AQP3, AQP8 and NF-κB p65. RT-PCR was performed to detect the expression of AQP1, AQP3, and AQP8.

Conclusions: Liquid water metabolic abnormalities and intestine permeability alteration might be the mechanism of IBS by down-regulating AQP1, AQP3 and AQP8 via NF-κB pathway.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 17565

Publication Alerts

Research Papers:

Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats’ colon via NF-κB pathway

Abstract