Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice

Tianjie Qi; Haitao Li; Shuai Li

doi:10.18632/oncotarget.17560

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice

Tianjie Qi, Haitao Li and Shuai Li _

PDF | HTML | How to cite

Oncotarget. 2017; 8:36658-36663. https://doi.org/10.18632/oncotarget.17560

Metrics: PDF 1511 views | HTML 2247 views | ?

Abstract

Tianjie Qi1,*, Haitao Li1,*, Shuai Li1

1Department of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China

*These authors contributed equally to this work and are co-first authors

Correspondence to:

Shuai Li, email: [email protected]

Keywords: indirubin, acute lung injury, oxidative stress, inflammation, NF-κB

Received: March 22, 2017 Accepted: April 07, 2017 Published: May 02, 2017

ABSTRACT

Indirubin, a traditional Chinese medicine formulation from the Muricidae family, has been reported to exhibit abroad anti-cancer and anti-inflammation activities and mediate nuclear factor-κB (NF-κB) signal. Thus, this study aimed to investigate the protective effects of indirubin on LPS-induced acute lung injury and the potential mechanism in mice. The results showed that LPS treatment caused oxidative stress and inflammation in mice. Indirubin alleviated LPS-caused oxidative stress and inflammation via reducing MDA abundance and IL-1β and TNF-α expressions in mice. Meanwhile, indirubin improved lung NO production and inhibited NF-κB activation caused by LPS exposure. In conclusion, indirubin alleviated LPS-induced acute lung injury via improving antioxidant and anti-inflammatory functions, which might be associated with the NO and NF-κB signals.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 17560

Publication Alerts

Research Papers:

Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice

Abstract