Oncotarget

Research Papers:

Retrospective analysis of risk factors associated with Kawasaki disease in China

Lihua Bai, Tienan Feng, Lifang Yang, Yi Zhang, Xuejuan Jiang, Kayiu Liu, Lihua Chen, Xiaoyan Feng, Yanming Rong, Yuehua Li, Zhiqiang Qin and Jing Qiao _

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Oncotarget. 2017; 8:54357-54363. https://doi.org/10.18632/oncotarget.17530

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Abstract

Lihua Bai1,*, Tienan Feng1,2,*, Lifang Yang3,*, Yi Zhang4,*, Xuejuan Jiang1, Kayiu Liu1, Lihua Chen1, Xiaoyan Feng1, Yanming Rong1, Yuehua Li3, Zhiqiang Qin1,5 and Jing Qiao1

1Department of Pediatrics, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University, Shanghai 200123, China

2Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

3Shanxi Provincial People’s Hospital, Xi’An Jiaotong University, Xi’an 710068, China

4The 3rd Clinical Medical School, Three Gorges University, Yichang 443002, China

5Departments of Genetics, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, New Orleans, LA 70112, USA

*These authors contributed equally to this work

Correspondence to:

Jing Qiao email: [email protected]

Zhiqiang Qin email: [email protected]

Keywords: Kawasaki disease (KD), typical KD, incomplete KD, IVIG ineffectiveness, retrospective analysis

Received: March 16, 2017     Accepted: April 14, 2017     Published: April 29, 2017

ABSTRACT

In order to provide early intervention for coronary artery lesion (CAL) caused by Kawasaki Disease (KD), we analyzed clinical characteristics of typical and incomplete KD cases from 1998 to 2008 in Northwest and Central China. A total of 383 patients included 298 cases of typical KD and 85 cases of incomplete KD. The morbidity of incomplete KD was 28.5%, a percentage significantly lower than that of typical KD. The occurrence of bulbar conjunctiva congestion, erythra, crissum red, film-like decrustation, lip red, rhagades, raspberry tongue, bilateral toe-end decrustation, limb sclerosis, cervical lymph nodes enlargement, agitation and irritability in incomplete KD group was lower than that in the group of typical KD (p < 0.05); however, the occurrence of unilateral toe-end decrustation, scar reappearance erythema, malaise, fatigue, liver incidence was significant higher in incomplete KD group (p < 0.05). Based on lab assays and inspection index comparisons, the incomplete KD cases whose C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were significantly increased, had significantly higher reduction in blood platelet (PLT). Interestingly, the KD patients with CPR higher than 30 mg/L, ESR higher than 40 mm/h, hepatomegaly and IVIG ineffectiveness, had higher incidence of CAL development. Altogether, our data have indicated differential clinical characteristics between incomplete KD and typical KD, and have identified several high risk factors of KD for CAL, such as hepatomegaly.


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