Oncotarget

Meta-Analysis:

Duct-to-mucosa versus invagination pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis

Shuisheng Zhang, Zhongmin Lan, Jianwei Zhang, Yingtai Chen, Quan Xu, Qinglong Jiang, Yajie Zhao, Chengfeng Wang _, Xiaoning Bi and Xiaozhun Huang

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Oncotarget. 2017; 8:46449-46460. https://doi.org/10.18632/oncotarget.17503

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Abstract

Shuisheng Zhang1,*, Zhongmin Lan1,*, Jianwei Zhang1, Yingtai Chen1, Quan Xu1, Qinglong Jiang1, Yajie Zhao1, Chengfeng Wang1, Xiaoning Bi2 and Xiaozhun Huang3

1Department of Abdominal Surgical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China

2Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China

3Department of Abdominal Surgery, Cancer Hospital of Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen Cancer Hospital, Shenzhen, 518116, China

*These authors have contributed equally to this work

Correspondence to:

Chengfeng Wang, email: [email protected]

Keywords: duct-to-mucosa, invagination, pancreaticojejunostomy (PJ), pancreaticoduodenectomy (PD), postoperative pancreatic fistula (POPF)

Received: October 27, 2016    Accepted: April 11, 2017    Published: April 28, 2017

ABSTRACT

Objective: We aimed to compare the two most commonly used pancreatico-jejunostomy reconstruction techniques—duct-to-mucosa and invagination.

Methods: Databases, including MEDLINE, EMBASE, Cochrane Library, and several clinical trial registration centers were searched. Randomized controlled trials that compared duct-to-mucosa and invagination pancreaticojejunostomy techniques after pancreaticoduodenectomy were included and analyzed.

Results: In total, seven RCTs were included, involving 850 patients. The difference in postoperative pancreatic fistula rate between the duct-to-mucosa and invagination pancreaticojejunostomy was not significant (RR = 1.03, 95% CI = 0.76-1.39, P = 0.86). There was no significant difference in clinically relevant postoperative pancreatic fistula between the two groups (RR = 0.78, 95% CI = 0.15-3.96, P = 0.77). The overall morbidity, overall mortality, delayed gastric emptying, intra-abdominal collection, reoperation rate, and length of hospital stay between the two groups were not significantly different. Sensitivity analysis showed that the meta-analysis was stable. Further, no significant publication bias was seen.

Conclusions: Duct-to-mucosa and invagination pancreaticojejunostomy techniques after pancreaticoduodenectomy were comparable in terms of postoperative pancreatic fistula incidence and other parameters.


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