Research Papers:

Diagnostic and prognostic values of endothelial-cell-specific molecule-1 with malignant pleural effusions in patients with non-small cell lung cancer

Guo-Jun Lu, Cheng-Jie Shao, Yu Zhang, Yong-Yue Wei, Wei-Ping Xie and Hui Kong _

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Oncotarget. 2017; 8:49217-49223. https://doi.org/10.18632/oncotarget.17455

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Guo-Jun Lu1,2, Cheng-Jie Shao1, Yu Zhang2, Yong-Yue Wei3, Wei-Ping Xie1 and Hui Kong1

1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

2Department of Respiratory Medicine, Nanjing Chest Hospital, School of Medicine, Southeast University, Nanjing 210029, China

3Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China

Correspondence to:

Wei-Ping Xie, email: [email protected]

Hui Kong, email: [email protected]

Keywords: ESM-1, non-small cell lung cancer, overall survival (OS), prognosis, biomarker

Received: March 22, 2017     Accepted: April 12, 2017     Published: April 27, 2017


Over-expressed endothelial-cell-specific molecule-1 (ESM-1) in tumor vascular endothelium contributes to tumor angiogenesis, metastasis, and poor prognosis. However, the content of ESM-1 in pleural effusion is unclear. A retrospective study was carried out to investigate the diagnostic and prognostic values of ESM-1 with malignant pleural effusions in patients with non-small cell lung cancer (NSCLC). ESM-1 levels in malignant pleural effusion (MPE) from 70 patients with NSCLC and 50 cases of benign pleural effusion (BPE) were measured using enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curve was calculated to assess the diagnostic value of ESM-1. Survival curves were performed by Kaplan-Meier method and survival characteristics were compared by log-rank test. Univariable and multivariate Cox proportional hazards model were carried out to analysis the significance of different prognostic factors for overall survival (OS). ESM-1 levels were significantly higher in MPE than those in BPE (p < 0.001). By ROC curve analysis, with a cutoff level of 19.58 ng/ml, the accuracy, sensitivity, and specificity for ESM-1 diagnosis MPE were 82.5%, 81.4%, and 84.0%, respectively. Moreover, NSCLC patients with pleural fluid ESM-1 levels below 19.58 ng/ml had significant longer OS than those patients with higher levels (22.09 months vs. 11.49 months, p = 0.003). Multivariate survival analysis showed that high MPE ESM-1 level was an independent prognostic factor (HR, 1.007; p = 0.039) for the OS of NSCLC patients. This study showed that ESM-1 level in pleural effusion could be a potential diagnostic and prognostic marker in NSCLC patients with MPE.

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