Oncotarget

Research Papers:

P53 prevent tumor invasion and metastasis by down-regulating IDO in lung cancer

Dongfang Tang, Lu Yue, Ruyong Yao, Lin Zhou, Yuqin Yang, Liming Lu and Wen Gao _

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Oncotarget. 2017; 8:54548-54557. https://doi.org/10.18632/oncotarget.17408

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Abstract

Dongfang Tang1, Lu Yue2, Ruyong Yao3, Lin Zhou4, Yuqin Yang4, Liming Lu4 and Wen Gao1

1Department of Thoracic Surgery, Huadong Hospital Affiliated to FuDan University, Huadong, China

2Department of Oncology of the Qingdao Municipal Hospital, Qingdao, China

3Central Laboratory of the Affiliated Hospital of Medical College Qingdao University, Qingdao, China

4Central Laboratory of Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, China

Correspondence to:

Wen Gao, email: [email protected]

Keywords: lung cancer, IDO signaling, p53, metastasis

Received: February 10, 2017     Accepted: March 29, 2017     Published: April 25, 2017

ABSTRACT

In present study, we are to clear demonstrate the genetic evidence of IDO signaling’s impact on invasion and metastasis in lung cancer. Here we examined IDO1 expression levels in non-small cell lung cancer (NSCLC) patients (64) tumor/normal pairs underwent RT-PCR and comprehensive histological, immunohistochemica and clinical analysis. The NSCLC cells stably expressing IDO1 was analyzed for migration and invasion assays and the regulatory mechanism in vitro and metastasis assays in vivo. As results, we reported that IDO1 expression increased by more than 3.2-fold in lung cancer compared with their corresponding non-tumor tissues, and the up-regulation of IDO1 is significantly correlated to TNM stage and lymph node-metastasis. The over-expression of IDO1 significantly encouraged the metastasis and invasion of lung cancer cells, and IDO1 could promote metastasis formation in vivo. Furthermore, we further found that p53 could attenuate IDO signaling in lung cancer cell migration partly. In conclusion, these results demonstrate that the IDO signaling’s impact on invasion and metastasis and the suppressive effect of p53 on IDO1 in lung cancer, present one novel therapeutic strategy for early metastatic lung cancer in clinical.


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