Clinical Research Papers:
To predict the radiosensitivity of nasopharyngeal carcinoma using intravoxel incoherent motion MRI at 3.0 T
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Wen Bo Chen2, Bin Zhang1,3, Long Liang1, Yu Hao Dong1,4, Guan Hui Cai2, Chang Hong Liang1, Bo Wen Lan2 and Shui Xing Zhang1
1 Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, Guangzhou, Guangdong, P.R. China
2 Department of Radiology, HuiZhou Municipal Central Hospital, Huizhou, Guangdong, P.R. China
3 Southern Medical University, Guangzhou, Guangdong, P.R. China
4 Shantou University Medical College, Shantou, Guangdong, P.R. China
Shui Xing Zhang, email:
Bo Wen Lan, email:
Keywords: intravoxel incoherent motion, MRI, nasopharyngeal carcinoma, IMRT, radiosensitivity
Received: August 04, 2016 Accepted: April 11, 2017 Published: April 21, 2017
Purpose: To investigate intravoxel incoherent motion (IVIM) MRI for evaluating the sensitivity of radiotherapy on nasopharyngeal carcinoma (NPC).
Results: The reproducibility between intra-observer and inter-observer was relatively good. D (0.72×10-3 mm2/s±0.14 vs. 0.54×10-3 mm2/s±0.23; P < 0.001) and D* (157.92×10-3 mm2/s±15.21 vs. 120.36×10-3 mm2/s±10.22; P < 0.0001) were significantly higher in effective group than poor-effective group, whereas the difference of f (18.79%±2.51 vs. 16.47%±1.51) and ADC (1.21×10-3 mm2/s±0.11 vs. 1.33×10-3 mm2/s±0.23) could not reach statistical significant between the 2 groups (P > 0.05).
Conclusions: IVIM may be potentially useful in assessing the radiosensitivity of NPC. The higher D value combining with higher D* value might indicate the more radiosensitive of NPC, and increased D* might reflect increased blood vessel generation and parenchymal perfusion in NPC.
Materials and Methods: Sixty consecutive patients (20 female, range, 27-83 years, mean age, 52 years) newly diagnosed NPC in the stage of T3 or T4 were enrolled. Forty-two of them were divided into effective group clinically after a standard radiotherapy according to the RECIST criteria. IVIM with 13 b-values (range, 0-800 s/mm2) and general MRI were performed at 3.0T MR scanner before and after radiotherapy. The parameters of IVIM including perfusion fraction (f), perfusion-related diffusion (D*), pure molecular diffusion (D) and apparent diffusion coefficient (ADC) were calculated. Two radiologists major in MRI diagnose analyzed all images independently and placed regions of interest (ROIs). Intra-class correlation coefficient (ICC) was used to evaluate intra-observer and inter-observer agreement. And Mann–Whitney test was used to assess the differences between the two groups.
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