Oncotarget

Research Papers:

Long non-coding RNAs may serve as biomarkers in breast cancer combined with primary lung cancer

Xianfeng Ding, Yuhan Zhang, Hongjian Yang, Weimin Mao, Bo Chen, Shifeng Yang, Xiaowen Ding, Dehong Zou, Wenju Mo, Xiangming He and Xiping Zhang _

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Oncotarget. 2017; 8:58210-58221. https://doi.org/10.18632/oncotarget.17356

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Abstract

Xianfeng Ding1,*, Yuhan Zhang1,*, Hongjian Yang2,*, Weimin Mao3, Bo Chen4, Shifeng Yang4, Xiaowen Ding2, Dehong Zou2, Wenju Mo2, Xiangming He2 and Xiping Zhang2

1College of Life Science, Zhejiang Sci-Tech University, Hangzhou 310008, Zhejiang Province, China

2Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China

3Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China

4Department of Pathology, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China

*These authors contributed equally to this work

Correspondence to:

Xiping Zhang, email: zxp99688@vip.163.com

Keywords: lncRNA, breast cancer combined with primary lung cancer, biomarkers

Received: December 28, 2016     Accepted: April 07, 2017     Published: April 21, 2017

ABSTRACT

Long non-coding RNAs (lncRNAs) have been shown to play important regulatory role in certain type of cancers biology, including breast and lung cancers. However, the lncRNA expression in breast cancer combined with primary lung cancer remains unknown. In this study, databases of the Cancer Genome Atlas (TCGA) and the lncRNA profiler of contained candidate 192 lncRNAs were utilized. 11 lncRNAs were differentially expressed in breast cancer, 9 candidate lncRNAs were differentially expressed in lung cancer. In order to find the aberrant expression of lncRNAs in breast cancer combined with primary lung cancer, seven samples of primary breast cancer and lung cancer were studied for the expression of selected lncRNAs. The results showed that SNHG6 and NEAT1 were reversely expressed in breast cancer combined with primary lung cancer compared with primary breast or lung cancer. In addition, a significant correlation of lncRNAs was found in the patients whose age was above 56 in breast cancer. What’s more, PVT1 expression was negatively correlated with the pathological stage, and the level of ER, PR, HER2, p53 in breast cancer. Furthermore, lncRNA expression did not have significant relationship with the 5-year survival of patients with breast cancer combined with primary lung cancer. The findings revealed that PVT1, SNHG6, NEAT1 may serve as a prognostic marker for breast cancer combined with primary lung cancer. Therefore, these lncRNAs are potential molecular indicators in the diagnosis and prognosis of cancer in the future.


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