Oncotarget

Research Papers:

The highly expressed COL4A1 genes contributes to the proliferation and migration of the invasive ductal carcinomas

Rongzhong Jin, Jia Shen, Tiancheng Zhang, Qiliang Liu, Caihua Liao, Hailin Ma, Sijing Li and Zhaoxia Yu _

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Oncotarget. 2017; 8:58172-58183. https://doi.org/10.18632/oncotarget.17345

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Abstract

Rongzhong Jin1,*, Jia Shen2,*, Tiancheng Zhang3,4,*, Qiliang Liu1, Caihua Liao1, Hailin Ma1, Sijing Li1 and Zhaoxia Yu5

1College of Biotechnology, Guilin Medical University, Guilin, China

2Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA

3Institute of Reproduction and Development, Fudan University, Shanghai, China

4China National Population and Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai Institute of Planned Parenthood Research (SIPPR), Shanghai, China

5Department of Medical Oncology, Central Hospital of Weihai, Weihai, Shandong, China

*These authors contributed equally to this work

Correspondence to:

Zhaoxia Yu, email: eihezuo@163.com

Keywords: IDC, biomarker, bioinformation, VCAN, COL4A1

Received: November 02, 2016     Accepted: April 10, 2017     Published: April 21, 2017

ABSTRACT

Background: Invasive ductal carcinoma is a kind of very typical breast cancer. The goal of our research was to figure out the molecular mechanism of Invasive ductal carcinoma and to find out its potential therapy targets.

Results: The total amount of 478 differentially expressed genes in Invasive ductal carcinoma which compared with normal breast epithelial cells were recognized. Functional enrichment analysis proved the most part of differentially expressed genes had connection with ECM-receptor interaction. The two genes lists were contrasted in PPI network, and miRNA regulation networks, The most two crucial genes were identified in our study, which may be helpful to improve Invasive ductal carcinoma treatment. Additionally, experimental results shows that the COL4A1 gene, one of identified genes, played important roles in both of proliferation and colony formation in Invasive ductal carcinoma.

Conclusions: Invasive ductal carcinoma could have connection with ECM-receptor mutations. These 9 vital genes could be an important part in the progression of Invasive ductal carcinoma and be offered as therapy targets and prognosis indicator. and the experimental results showed that one of the most crucial genes, COL4A1, was the key gene that influence the proliferation and colony formation of the Invasive ductal carcinoma cell.


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