Research Papers:

The combination of prostate imaging reporting and data system version 2 (PI-RADS v2) and periprostatic fat thickness on multi-parametric MRI to predict the presence of prostate cancer

Yudong Cao, Min Cao, Yuke Chen, Wei Yu, Yu Fan, Qing Liu, Ge Gao, Zheng Zhao, Xiaoying Wang and Jie Jin _

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Oncotarget. 2017; 8:44040-44049. https://doi.org/10.18632/oncotarget.17182

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Yudong Cao1,2*, Min Cao3,*, Yuke Chen1,2,*, Wei Yu1,2, Yu Fan1,2, Qing Liu3, Ge Gao3, Zheng Zhao1,2, Xiaoying Wang3 and Jie Jin1,2

1Department of Urology, Peking University First Hospital, Beijing, China

2Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China

3Department of Radiology, Peking University First Hospital, Beijing, China

*These authors have contributed equally to this work

Correspondence to:

Jie Jin, email: [email protected]

Xiaoying Wang, email: [email protected]

Keywords: periprostatic fat, prostate cancer, diagnosis, PI-RADS, nomogram

Received: December 20, 2016    Accepted: March 27, 2017    Published: April 18, 2017


Purpose: To evaluate the auxiliary effectiveness of periprostatic fat thickness (PPFT) on multi-parametric magnetic resonance imaging (mp-MRI) to Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) in predicting the presence of prostate cancer (PCa) and high-grade prostate cancer (HGPCa, Gleason Score ≥ 7).

Results: Overall, there were 371 patients (54.3%) with PCa and 292 patients (42.8%) with HGPCa. The mean value of PPFT was 4.04 mm. Multivariate analysis revealed that age, prostatic specific antigen (PSA), volume, PI-RADS score, and PPFT were independent predictors of PCa. All factors plus abnormal digital rectal exam were independent predictors of HGPCa. In addition, the PPFT was the independent predictor of PCa (Odds ratio [OR] 2.56, p = 0.004) and HGPCa (OR 2.70, p = 0.014) for subjects with PI-RADS grade 3. The present two nomograms based on multivariate analysis outperformed the single PI-RADS in aspects of predicting accuracy for PCa (area under the curve: 0.922 vs. 0.883, p = 0.029) and HGPCa (0.919 vs. 0.873, p = 0.007). Decision-curve analysis also indicated the favorable clinical utility of the present two nomograms.

Materials and Methods: The clinical data of 683 patients who received transrectal ultrasound guided biopsy and prior mp-MRI were reviewed. PPFT was measured as the shortest perpendicular distance from the pubic symphysis to the prostate on MRI. Univariate and multivariate analyses were performed to determine the independent predictors of PCa and HGPCa. We also constructed two nomograms for predicting PCa and HGPCa based on the logistic regression.

Conclusion: The PPFT on mp-MRI is an independent predictor of PCa and HGPCa, notably for patients with PI-RADS grade 3. The nomograms incorporated predictors of PPFT and PI-RADS demonstrated good predictive performance.

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