Research Papers:

Expression pattern of estroprogestinic receptors in sinonasal inverted papilloma

Agostino Serra, Rosario Caltabiano, Giacomo Spinato, Salvatore Gallina, Salvatore Caruso, Venerando Rapisarda, Paola Di Mauro, Veronica Castro, Angelo Conti, Luisa Licciardello, Luigi Maiolino, Salvatore Lanzafame and Salvatore Cocuzza _

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Oncotarget. 2017; 8:38962-38968. https://doi.org/10.18632/oncotarget.17161

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Agostino Serra1, Rosario Caltabiano2, Giacomo Spinato3, Salvatore Gallina4, Salvatore Caruso5, Venerando Rapisarda6, Paola Di Mauro1, Veronica Castro1, Angelo Conti1, Luisa Licciardello1, Luigi Maiolino1, Salvatore Lanzafame2, Salvatore Cocuzza1

1Department of Medical and Surgical Sciences and Advanced Technologies “G. Ingrassia”, ENT Section, University of Catania, Catania, Italy

2Department of Medical and Surgical Sciences and Advanced Technologies “G. Ingrassia”, Section of Anatomic Pathology, University of Catania, Catania, Italy

3ENT Department, Rovigo Provincial Hospital, Rovigo, Italy

4Department of Experimental Biomedicine and Clinical Neurosciences, Otolaryngology Unit, University of Palermo, Palermo, Italy

5Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic and Research Group for Sexology, University of Catania, Catania, Italy

6Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy

Correspondence to:

Salvatore Cocuzza, email: [email protected]

Keywords: paranasal sinuses, inverted papilloma, human papilloma virus, hormonal receptor expression, immunohistochemistry

Received: January 13, 2017     Accepted: April 03, 2017     Published: April 17, 2017


Inverted papilloma (IP) is a locally destructive, benign neoplasm of the nose and paranasal sinuses with a high tendency for recurrence, a significant potential for malignancy, and an etiology that today is still uncertain. The expression of hormonal receptors in neoplastic tissues has been the focus of intensive research for its potential diagnostic, prognostic, and therapeutic significance. The aim of this study was to assess the potential estroprogestinic receptor expression in patients undergoing sinus surgery for IP. A retrospective study was carried out, on surgical specimens of 73 patients who underwent endoscopic sinus surgery for first manifestation of sinonasal IP (primitive IP group) and in 21 subjects who had developed a recurrence (relapsed IP group). The results of the immunohistochemical analysis of the first group showed the absence of receptor expression for PGR in all cases analyzed and the presence of a low positivity for ER in 11 cases (P > 0.082). Similarly, in the second group the results showed a low presence of ER receptors in 3 of the 21 cases (P > 0.068), while there was no evidence of PGR receptors in the examined samples. In addition, in 11 of the cases only 3 were considered positive (27.2%) showing a recurrence during follow-up (P > 0.068).

Our results suggest that the sinonasal IP is a benign tumor independent of estrogen and progesterone, and the receptors for these hormones are therefore unsuitable as predictors of relapse or possible prognostic indicators and therapeutic targets.

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