Oncotarget

Clinical Research Papers:

Dual time-point 18F-FDG PET/CT imaging with multiple metabolic parameters in the differential diagnosis of malignancy-suspected bone/joint lesions

Chen-Tian Shen, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Xin-Yun Zhang and Quan-Yong Luo _

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Oncotarget. 2017; 8:71188-71196. https://doi.org/10.18632/oncotarget.17140

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Abstract

Chen-Tian Shen1,*, Zhong-Ling Qiu1,*, Zhen-Kui Sun1, Wei-Jun Wei1, Hong-Jun Song1, Xin-Yun Zhang1 and Quan-Yong Luo1

1Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Quan-Yong Luo, email: [email protected]

Keywords: dual time-point imaging, 18F-FDG PET/CT, metabolic tumor volume, total lesional flycolysis, bone/joint lesions

Received: October 20, 2016    Accepted: March 22, 2017    Published: April 17, 2017

ABSTRACT

The purpose of this study was to evaluate the diagnostic potential of dual time-point 18F-FDG PET/CT imaging with multiple metabolic parameters in malignancy-suspected bone/joint lesions. Fifty seven consecutive patients were recruited. PET parameters including SUVmax, SUVmean, metabolic tumor volume (MTV), total lesional glycolysis (TLG) and retention indexes (RIs) were obtained. Thirty five malignant and 22 benign lesions were confirmed by pathology. In all, 48 receiver operating characteristic (ROC) curves were derived. For SUVmax, MTV2.0, TLG2.0, MTV2.5 and TLG2.5, areas under the curves (AUCs) of early time-point imaging were similar to those of delayed time (P > 0.05), while higher than those of dual time (P< 0.05). For MTV50%max, TLG50%max, MTV75%max and TLG75%max, AUCs of early time-point imaging were lower than those of delayed time (P< 0.05), while similar to those of dual time (P> 0.05). In conclusion, dual time-point 18F-FDG PET/CT imaging shows limited value in the differential diagnosis of malignancy-suspected bone/joint lesions. However, MTV and TLG at a fixed SUV threshold (50% or 75% of SUVmax) in delayed time-point imaging may provide better diagnostic accuracy.


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