Erectile dysfunction and the risk of prostate cancer
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Wei-Yu Lin1,2,3, Ying-Hsu Chang4, Cheng-Li Lin5,6, Chia-Hung Kao7,8,9 and Hsi-Chin Wu10,11
1Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Gia-Yi, Taiwan
2Chang Gung University of Science and Technology, Chia-Yi, Taiwan
3Department of Medicine, Chang Gung University, Taoyuan, Taiwan
4Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKo, Taiwan
5Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
6School of Medicine, China Medical University, Taichung, Taiwan
7Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan
8Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
9Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan
10Department of Urology, China Medical University Hospital, Taichung, Taiwan
11Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
Hsi-Chin Wu, email: firstname.lastname@example.org
Keywords: Prostate cancer (PCa), erectile dysfunction (ED), Cohort study, National Health Insurance Research Database, malignancy
Received: October 19, 2016 Accepted: March 21, 2017 Published: April 13, 2017
Background: Prostate cancer (PCa) is the most commonly diagnosed malignancy and the third leading cause of cancer death among men in developed countries. Because some risk factors are common between erectile dysfunction (ED) and PCa, we investigated the association between ED and subsequent PCa.
Methods: This nationwide population-based cohort study used data from the Taiwan National Health Insurance Research Database for the period 2000–2010. We identified patients newly diagnosed with ED by using codes from the International Classification of Diseases, Ninth Revision, Clinical Modification.
Results: In total, 5858 and 23432 patients were enrolled in the ED and non-ED cohorts, respectively. After adjustment for age, sex, and comorbidities, the overall incidence densities of PCa were significantly higher in the ED cohort than in the non-ED cohort, with an adjusted hazard ratio (aHR) of 1.19. The age-specific relative risk of PCa was significantly higher for all age groups in the ED cohort than in the non-ED cohort. Compared with patients without ED, those with organic ED had a 1.27-fold higher risk of PCa.
Conclusion: ED is a harbinger of PCa in some men. Physicians should consider the possibility of occult PCa in patients with ED regardless of age and comorbidities.
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