Long non-coding RNAs in renal cell carcinoma: A systematic review and clinical implications

Ming Li, Ying Wang, Liang Cheng, Wanting Niu, Guoan Zhao, Jithin K. Raju, Jun Huo, Bin Wu, Bo Yin, Yongsheng Song and Renge Bu _

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Oncotarget. 2017; 8:48424-48435. https://doi.org/10.18632/oncotarget.17053

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Ming Li1, Ying Wang2,3, Liang Cheng4, Wanting Niu5, Guoan Zhao6, Jithin K. Raju7, Jun Huo1, Bin Wu1, Bo Yin1, Yongsheng Song1 and Renge Bu1

1Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China

2Department of Nuclear Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China

3Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA

4Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA

5Department of Orthopedics, Brigham and Women’s Hospital, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts 02115, USA

6School of Network Education, Beijing University of Posts and Telecommunications, Hebei, Beijing 100088, P.R. China

7Department of Clinical Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China

Correspondence to:

Renge Bu, email: burg@sj-hospital.org

Keywords: renal cell carcinoma, lncRNA, diagnosis, prognosis, therapy

Received: November 18, 2016     Accepted: March 20, 2017     Published: April 12, 2017


Renal cell carcinoma is one of the most common malignancy in adults, its prognosis is poor in an advanced stage and early detection is difficult due to the lack of molecular biomarkers. The identification of novel biomarkers for RCC is an urgent and meaningful project. Long non-coding RNA (lncRNA) is transcribed from genomic regions with a minimum length of 200 bases and limited protein-coding potential. Recently, lncRNAs have been greatly studied in a variety of cancer types. They participate in a wide variety of biological processes including cancer biology. In this review, we provide a new insight of the profiling of lncRNAs in RCC and their roles in renal carcinogenesis, with an emphasize on their potential in diagnosis, prognosis and potential roles in RCC therapy.

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