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p-Akt as a potential poor prognostic factor for gastric cancer: a systematic review and meta-analysis

Fang Cao, Cong Zhang, Wei Han _, Xiao-Jiao Gao, Jun Ma, Yong-Wei Hu, Xing Gu, Hou-Zhong Ding, Li-Xia Zhu and Qin Liu

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Oncotarget. 2017; 8:59878-59888. https://doi.org/10.18632/oncotarget.17001

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Abstract

Fang Cao1,*, Cong Zhang2,*, Wei Han1, Xiao-Jiao Gao3, Jun Ma4, Yong-Wei Hu1, Xing Gu5, Hou-Zhong Ding1, Li-Xia Zhu5 and Qin Liu5

1Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China

2Department of Pharmacy, Kunshan Hospital of TCM, Kunshan, Jiangsu 215300, P.R. China

3Department of Pathology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China

4Department of Urological Surgery, Kunshan Hospital of TCM, Kunshan, Jiangsu 215300, P.R. China

5Department of Gynaecology and Obstetrics, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China

*These authors have contributed equally to this work

Correspondence to:

Wei Han, email: hans64@126.com

Keywords: p-Akt, gastric cancer, prognosis, survival, meta-analysis

Received: January 04, 2017     Accepted: March 17, 2017     Published: April 10, 2017

ABSTRACT

To understand the relationship between p-Akt expression and the prognosis of patients with gastric cancer, we searched six databases, Pubmed, EMBASE, Cochrane Library, CNKI, Wanfang and CBM for relevant articles in order to conduct this metaanalysis. The pooled hazard ratios and corresponding 95%CI of overall survival were calculated to evaluate the prognostic value of p-Akt expression in patients with gastric cancer. With 2261 patients combined from 13 available studies, the pooled HR showed a poor prognosis in patients with gastric cancer in the univariate analysis (HR=1.88, 95%CI:1.45-2.43, P<0.00001), and the group “univariate analysis+estimate” (HR=1.41, 95%CI: 1.01-1.97, P=0.04), but not in multivariate analysis (HR=0.66, 95%CI: 0.29-1.52, P=0.33) and estimate (HR=1.13, 95%CI: 0.65-1.95, P=0.67). In conclusion, our results indicated that p-Akt was likely to be an indicator of poor prognosis in patients with gastric cancer.


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