Research Papers:

Comprehensive analysis of interleukin-8 gene polymorphisms and periodontitis susceptibility

Xiao-Bing Ni, Cheng Jia, He-Dong Yu, Yan-Qin Li, Xian-Tao Zeng and Wei-Dong Leng _

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Oncotarget. 2017; 8:48996-49004. https://doi.org/10.18632/oncotarget.16922

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Xiao-Bing Ni1,*, Cheng Jia2,*, He-Dong Yu1,*, Yan-Qin Li1, Xian-Tao Zeng1 and Wei-Dong Leng1

1Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China

2Department of Orthodontics, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

*These authors contributed equally to this work

Correspondence to:

Wei-Dong Leng, email: [email protected]

Keywords: interleukin-8, periodontitis, periodontal diseases, meta-analysis, polymorphism

Received: February 14, 2017     Accepted: March 09, 2017     Published: April 07, 2017


Background: Associations between interleukin-8 (IL-8) gene polymorphisms and periodontitis susceptibility have been investigated in many published studies, but the conclusions are still inconsistent. Therefore, we performed this systematic review and meta-analysis to review which polymorphisms have been researched and to obtain a precise result of the same polymorphism from different studies.

Results: Finally 10 publications involving 1938 patients and 1569 controls were yielded, including 12 polymorphisms. Six studies investigated rs4073 polymorphism; two focused on rs2227306 and rs2227307; two referred to rs2227532 and T-738A; one detected rs2230054, rs1126579 and rs1126580; one inspected A2767T, T11722T2 and C1633T, and one for rs2234671 polymorphism. Of them, IL-8 C1633T and rs1126580 polymorphisms showed positive association while the other ten polymorphisms revealed negative results.

Materials and methods: A comprehensive literature search from PubMed, Web of Science, and Chinese National Knowledge Infrastructure was conducted for all potentially relevant studies published before January 2, 2017. Two authors selected the studies and extracted data. The pooled analysis was conducted using the RevMan 5.1 software if a polymorphism was reported by two or more studies.

Conclusions: Based on current evidence, the IL-8 rs4073, A2767T, T11722T2, rs2234671, rs2230054, rs1126579, rs2227306, rs2227307, rs2227532, and T-738A polymorphisms were not associated with periodontitis susceptibility; the IL-8 C1633T and rs1126580 polymorphisms were associated with increased risk of periodontitis.

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