Oncotarget

Research Papers:

The p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma in a Polish population

Artur Kowalik _, Danuta Gąsior-Perczak, Martyna Gromek, Monika Siołek, Agnieszka Walczyk, Iwona Pałyga, Małgorzata Chłopek, Janusz Kopczyński, Ryszard Mężyk, Aldona Kowalska and Stanisław Góźdź

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Oncotarget. 2017; 8:58304-58308. https://doi.org/10.18632/oncotarget.16870

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Abstract

Artur Kowalik1,2, Danuta Gąsior-Perczak3, Martyna Gromek1, Monika Siołek4, Agnieszka Walczyk3, Iwona Pałyga3, Małgorzata Chłopek1, Janusz Kopczyński5, Ryszard Mężyk6, Aldona Kowalska3 and Stanisław Góźdź7,8

1Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland

2Department of Surgery and Surgical Nursing with The Scientific Research Laboratory, The Faculty of Health Sciences of The Jan Kochanowski University, Kielce, Poland

3Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland

4Genetic Clinic, Holycross Cancer Centre, Kielce, Poland

5Department of Surgical Pathology, Holycross Cancer Centre, Kielce, Poland

6Cancer Epidemiology, Holycross Cancer Centre, Kielce, Poland

7Oncology Clinic, Holycross Cancer Centre, Kielce, Poland

8The Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

Correspondence to:

Artur Kowalik, email: arturko@onkol.kielce.pl

Keywords: p.G534E, sporadic papillary thyroid carcinoma, HABP2, thyroid cancer, non-medullary thyroid cancer

Received: October 20, 2016     Accepted: March 09, 2017     Published: April 06, 2017

ABSTRACT

Thyroid cancer is one of the most frequently diagnosed cancers of the endocrine system. There are no known genetic risk factors for non-medullary thyroid cancer, other than a small number of hereditary syndromes; however, approximately 5% of non-medullary thyroid cancer, designated familial non-medullary thyroid cancer, exhibits heritability. The p.G534E (c.1601G>A) variant of HABP2 was recently reported as a risk factor for familial non-medullary thyroid cancer, including papillary thyroid carcinoma. We analyzed the incidence of the c.1601G>A variant of HABP2 in a Polish population consisting of 326 cases of papillary thyroid carcinoma and 400 control individuals by DNA genotyping, performed by Sanger sequencing. The c.1601G>A variant was detected in 3.7% of sporadic papillary thyroid carcinoma cases and 4.7% of healthy controls, and we did not detect an association between this variant and sporadic papillary thyroid carcinoma risk (OR = 0.71, 95% CI: 0.33–1.51; p = 0.3758). Additionally, no significant associations were identified between clinical and pathological disease features, response to primary treatment, and clinical status at the end of the observation, and HABP2 c.1601G>A genotype. In conclusion, the p.G534E variant of HABP2 is not associated with sporadic papillary thyroid carcinoma risk in the Polish population.


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