Research Papers:

Systemic inflammation response index (SIRI) predicts prognosis in hepatocellular carcinoma patients

Litao Xu, Shulin Yu, Liping Zhuang, Peng Wang, Yehua Shen, Junhua Lin and Zhiqiang Meng _

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Oncotarget. 2017; 8:34954-34960. https://doi.org/10.18632/oncotarget.16865

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Litao Xu1,2,*, Shulin Yu1,2,*, Liping Zhuang1,2,*, Peng Wang1,2, Yehua Shen1,2, Junhua Lin1,2, Zhiqiang Meng1,2

1Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

*These authors contributed equally to this work and should be considered co-first authors

Correspondence to:

Zhiqiang Meng, email: [email protected], [email protected]

Keywords: hepatocellular carcinoma, systemic inflammation response index, local therapy, systemic therapy, survival

Received: August 01, 2016     Accepted: March 24, 2017     Published: April 05, 2017


The systemic inflammation response index (SIRI) is a useful tool for predicting prognosis in some types of cancer. In this retrospective study, we evaluated the efficacy of SIRI in predicting overall survival in hepatocellular carcinoma (HCC) patients following local or systemic therapy. A cutoff value of 1.05 was identified for SIRI using ROC analysis in a training patient cohort. In the validation cohort, survival analysis revealed that median overall survival was longer in HCC patients with SIRI scores < 1.05 than in those with scores ≥ 1.05. Cox analysis of the validation cohort demonstrated that SIRI was associated with overall survival and was more predictive of overall survival that the AFP level or Child-Pugh score. However, SIRI and Barcelona Clinic Liver Cancer (BCLC) stage were equally effective for predicting survival. In addition, HCC patients with BCLC stage C had higher SIRI scores and poorer overall survival. SIRI also correlated with liver function parameters. Thus SIRI may be a convenient, low cost and reliable tumor marker for predicting prognosis in HCC patients.

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