SNM1B/Apollo in the DNA damage response and telomere maintenance

Maren Schmiester and Ilja Demuth _

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:48398-48409. https://doi.org/10.18632/oncotarget.16864

Metrics: PDF 1306 views  |   HTML 2219 views  |   ?  


Maren Schmiester1,2 and Ilja Demuth1,2,3

1Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany

2Institute of Medical and Human Genetics, Charité–Universitätsmedizin Berlin, 13353 Berlin, Germany

3Research Group on Geriatrics, Charité–Universitätsmedizin Berlin, 13347 Berlin, Germany

Correspondence to:

Ilja Demuth, email: ilja.demuth@charite.de

Keywords: Apollo, hSNM1B, DCLRE1B, Fanconi anemia

Received: February 21, 2017     Accepted: March 27, 2017     Published: April 05, 2017


hSNM1B/Apollo is a member of the highly conserved β-CASP subgroup within the MBL superfamily of proteins. It interacts with several DNA repair proteins and functions within the Fanconi anemia pathway in response to DNA interstrand crosslinks. As a shelterin accessory protein, hSNM1B/Apollo is also vital for the generation and maintenance of telomeric overhangs. In this review, we will summarize studies on hSNM1B/Apollo's function, including its contribution to DNA damage signaling, replication fork maintenance, control of topological stress and telomere protection. Furthermore, we will highlight recent studies illustrating hSNM1B/Apollo’s putative role in human disease.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 16864