Oncotarget

Research Papers:

Endobronchial ultrasound transbronchial biopsy with guide-sheath for the diagnosis of solitary pulmonary nodules

Chun-Hua Xu _, Qi Yuan, Li-Ke Yu, Wei Wang and Yong Lin

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Oncotarget. 2017; 8:58272-58277. https://doi.org/10.18632/oncotarget.16813

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Abstract

Chun-Hua Xu1,2,*, Qi Yuan1,2,*, Li-Ke Yu1,2, Wei Wang1,2 and Yong Lin3

1Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu 210029, China

2Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu 210029, China

3Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu 210029, China

*These authors have contributed equally to this work

Correspondence to:

Chun-Hua Xu, email: xuchunhua_nj@163.com

Keywords: endobronchial ultrasound, transbronchial biopsy, guide-sheath, solitary pulmonary nodules

Received: December 08, 2016    Accepted: March 16, 2017    Published: April 04, 2017

ABSTRACT

The aim of this study was to assess the usefulness of endobronchial ultrasound transbronchial biopsy with guide-sheath (EBUS-GS-TBB) for the diagnosis of solitary pulmonary nodules (SPNs). One hundred and eighty patients, who were diagnosed with SPNs and underwent an endobronchial ultrasound procedure. The diagnostic yield, safety and the associated factors were analyzed. Mean EBUS-GS procedure time was 14±8 min. The average number of biopsy specimens obtained in each SPNs was 5±1.2. One hundred and thirty-four SPNs were diagnosed by EBUS-GS-TBB and the diagnostic rate was 74.4 %. The diagnosis rate of malignancy was 83.3 %, while that of benign disease was 56.7 %. The most important factors that helped enhance EBUS-GS diagnostic accuracy included lesion diameter greater than 20mm, EBUS probe within the lesions and central lesions. No pneumothorax, hemoptysis or other serious complications occurred with the diagnostic procedures. EBUS-GS-TBB is a safe and effective method for diagnosing SPNs.


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