Oncotarget

Research Papers:

Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

Xia Chen, Rui Wu, Yiwei Kong, Yuting Yang, Yu Gao, Dandan Sun, Qizhen Liu, Dongjun Dai, Zeyuan Lu, Niansong Wang, Sheng Ge and Feng Wang _

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Oncotarget. 2017; 8:31915-31922. https://doi.org/10.18632/oncotarget.16651

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Abstract

Xia Chen1,*, Rui Wu1,*, Yiwei Kong1,*, Yuting Yang1,*, Yu Gao1, Dandan Sun1, Qizhen Liu1, Dongjun Dai1, Zeyuan Lu1, Niansong Wang1, Sheng Ge3, Feng Wang1,2

1Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

2Department of Nephrology, Shanghai Eighth People’s Hospital, Shanghai 200233, China

3Department of Clinical Nutrition, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

*These authors contributed equally to this work

Correspondence to:

Sheng Ge, email: gesheng607@126.com

Feng Wang, email: zyzwq1030@163.com

Keywords: tanshinone, kidney, diabetes

Received: January 25, 2017     Accepted: March 02, 2017     Published: March 29, 2017

ABSTRACT

Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN.


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