Clinical Research Papers:

Therapeutic evaluation of arterio-portal fistula-related gastroesophageal variceal bleeding

Xiaoquan Huang, Wen Zhang, Shiyao Chen _, Chengfeng Liu, Ruofan Sheng, Feng Li, Jian Wang, Jianjun Luo and Pengju Xu

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Oncotarget. 2017; 8:66584-66592. https://doi.org/10.18632/oncotarget.16579

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Xiaoquan Huang1, Wen Zhang2, Shiyao Chen1, Chengfeng Liu1, Ruofan Sheng3, Feng Li1, Jian Wang1, Jianjun Luo2 and Pengju Xu3

1 Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China

2 Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

3 Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

Correspondence to:

Shiyao Chen, email:

Keywords: combination treatment; portal hypertension; intrahepatic arterio-portal fistula; upper gastrointestinal bleeding

Received: January 31, 2017 Accepted: March 14, 2017 Published: March 25, 2017


Background & Aims: Intrahepatic arterio-portal fistula is an uncommon etiology of portal hypertension, which presents diagnostic and therapeutic challenges. This study aimed to assess the efficacy and outcomes of gastroesophageal variceal bleeding caused by arterio-portal fistula using different therapeutic approaches.

Methods: Medical records of 451 consecutive patients with arterio-portal fistula were reviewed from January 1, 2009, to July 15, 2016, and patients suffered variceal bleeding were eligible for the study.

Results: Among 57 patients with arterio-portal fistula, hepatocellular carcinoma was existed in 61.4% patients. A combination of radiological intervention and endoscopic treatment was performed in 8 (14.0%) patients; the remainder were treated using radiological intervention alone (n = 20, 35.1%), endoscopic treatment alone (n = 18, 31.6%), or without any intervention (n = 11, 19.3%). No patient died in the combination group, while 20 patients in the single-treatment group and 6 in the untreated group died during follow-up. A significant difference in the survival rate was found between the combination group and the other two groups. Treatment selection between combination and untreated groups was the only parameter significantly associated with survival (p = 0.002).

Conclusions: For patients diagnosed with arterio-portal fistula, combination treatment is the most optimal strategy in managing variceal bleeding, especially in patient with severe type of fistula.

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