Research Papers:

Patients with uterine leiomyoma exhibit a high incidence but low mortality rate for breast cancer

Te-Chun Shen, Te-Chun Hsia, Chieh-Lun Hsiao, Cheng-Li Lin, Chih-Yi Yang, Khay-Seng Soh, Liang-Chih Liu, Wen-Shin Chang, Chia-Wen Tsai and Da-Tian Bau _

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Oncotarget. 2017; 8:33014-33023. https://doi.org/10.18632/oncotarget.16520

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Te-Chun Shen1,2,3, Te-Chun Hsia1,2,3, Chieh-Lun Hsiao3, Cheng-Li Lin4, Chih-Yi Yang5, Khay-Seng Soh6, Liang-Chih Liu6, Wen-Shin Chang3, Chia-Wen Tsai3, Da-Tian Bau1,3,7

1Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

3Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan

4Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

5Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan

6Department of Breast Surgery, China Medical University Hospital, Taichung, Taiwan

7Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan

Correspondence to:

Da-Tian Bau, email: [email protected]

Keywords: breast cancer, uterine leiomyoma, cohort study

Received: December 21, 2016     Accepted: March 02, 2017     Published: March 23, 2017


The association of uterine leiomyoma with increased risk of breast cancer is controversial. Therefore, we used the National Health Insurance Research Database of Taiwan to examine breast cancer incidence and mortality among Asian patients with and without uterine leiomyoma. We compared breast cancer incidence and mortality between 22,001 newly diagnosed uterine leiomyoma patients and 85,356 individuals without uterine leiomyoma matched by age and date of diagnosis. Adjusted hazard ratios for breast cancer were estimated using the Cox model. The incidence of breast cancer was 35% higher in the uterine leiomyoma group than the leiomyoma-free group (1.65 vs. 1.22 per 1,000 individuals, p < 0.001), with an adjusted hazard ratio of 1.31 (95% confidence interval = 1.13−1.52). Interestingly, overall mortality was lower (4.12%) in the uterine leiomyoma group (mean followed time, 3.59 ± 2.70 years) than the leiomyoma-free group (8.78%; mean followed time, 3.54 ± 2.67 years) at the endpoint of the study (p <0.05). These findings indicate the incidence of breast cancer is higher in patients with uterine leiomyoma than in those without it, but overall mortality from breast cancer was lower in the patients with uterine leiomyoma.

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