Oncotarget

Research Papers:

Characteristics of prostate cancer detection rate (PCDR) in Chinese Han population under different prostate biopsy methods

Yongsheng Pan, Bianjiang Liu, Yuan Huang, Jun Wang, Xiao Li, Cheng Zhang, Jie Wu, Yuxiao Zheng, Chao Qin, Gong Cheng, Lixin Hua _ and Zengjun Wang

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Oncotarget. 2017; 8:32930-32936. https://doi.org/10.18632/oncotarget.16512

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Abstract

Yongsheng Pan1,*, Bianjiang Liu1,*, Yuan Huang1,*, Jun Wang1, Xiao Li1, Cheng Zhang1, Jie Wu1, Yuxiao Zheng1, Chao Qin1, Gong Cheng1, Lixin Hua1, Zengjun Wang1

1Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

*These authors contributed equally to this work

Correspondence to:

Lixin Hua, email: lixinhua@njmu.edu.cn

Gong Cheng, email: drg_cheng@163.com

Keywords: prostate cancer, biopsy, Chinese Han population, diagnosis

Received: October 19, 2016     Accepted: March 14, 2017     Published: March 23, 2017

ABSTRACT

We analyzed the improvement of prostate cancer detection rate (PCDR) in Chinese Han population and summarized the characteristics of prostate cancer (PCa) with the advancement of prostate biopsy technologies. From March 1999 to March 2015, 3762 patients underwent the systematic 6-, 8- or 13-core biopsy, guided by finger or transrectal ultrasound (TRUS) at our center. The PCDR under different PSA intervals and different biopsy methods were analyzed. The trends of PSA level, age and Gleason score of PCa patients were summarized. The PCDR of finger-guided 6- and 8-core biopsies were 30.8% (340/1103) and 36.7% (147/401) respectively. In 2258 patients with TRUS-guided 13-core biopsies, 992 (43.9%) were diagnosed as PCa, higher than that with finger-guided biopsies (43.9% vs. 32.4%, p < 0.001). The PCDR of prostate peripheral zone was higher than that of medial zone (37.5% vs. 31.4%, p < 0.001). Interestingly, the PCDR of extra 13th core was higher than the mean positive rate of other 12 cores (70.7% vs. 56.0%, p < 0.001). The systematic 13-core prostate biopsy guided by TRUS is safe, effective, and economic for PCa diagnosis in developing countries like China. The extra 13th core biopsy is beneficial to increase the PCDR.


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