Oncotarget

Research Papers:

Transarterial chemoembolization combined with computed tomography-guided 125iodine implantation enhances survival in hepatocellular carcinoma patients with portal vein tumor thrombus

Hong Tao Hu, Jun Peng Luo, Hai-Liang Li _, Chen Yang Guo, Quan Jun Yao, Xiang Geng and Li Jiang

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Oncotarget. 2017; 8:29258-29268. https://doi.org/10.18632/oncotarget.16491

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Abstract

Hong Tao Hu1, Jun Peng Luo1, Hai-Liang Li1, Chen Yang Guo1, Quan Jun Yao1, Xiang Geng1, Li Jiang1

1Department of Radiology and Research Institute of Radiology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan Province 450003, P. R. China

Correspondence to:

Hai-Liang Li, email: irlihailiang@163.com

Keywords: hepatocellular carcinoma, portal vein tumor thrombus, transarterial chemoembolization, 125iodine implantation, computed tomography-guided

Received: October 11, 2016     Accepted: February 14, 2017     Published: March 23, 2017

ABSTRACT

We conducted a retrospective study to evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with computed tomography-guided 125iodine implantation (TACE-125iodine) in hepatocellular carcinoma (HCC) patients with type B portal vein tumor thrombus (PVTT). From medical records, we determined that 50 patients who received 125iodine implantation 4-7 days after the first TACE session showed better survival than 50 patients who received only TACE (median survival, 13.1 vs. 6.0 months; P<0.01). Moreover, the PVTT control rate was higher in the TACE-125iodine than TACE alone group (78% vs. 18%; P<0.01). Multivariate analysis demonstrated that the TACE-125iodine procedure was an independent prognostic factor for overall survival. We also observed that bilirubin levels were increased at 4 weeks, indicating that 125iodine seeding in the PVTT beneficially impacted the small bile duct, which is proximal to the portal vein. No severe adverse events were observed in patients that received 125iodine seed implantation, and the mild adverse events were successfully treated. This study shows that TACE-125iodine therapy enhances patient survival with minimal adverse events. It is also more affordable than sorafenib, which is currently the recommended therapy for advanced HCC patients with PVTT.


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