Oncotarget

Research Papers:

Integrated analysis profiles of long non-coding RNAs reveal potential biomarkers of drug resistance in lung cancer

Wenhua Xue, Lifeng Li, Xin Tian, Zhirui Fan, Ying Yue, Chaoqi Zhang, Xianfei Ding, Xiaoqin Song, Bingjun Ma, Yunkai Zhai, Jingli Lu, Quancheng Kan and Jie Zhao _

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Oncotarget. 2017; 8:62868-62879. https://doi.org/10.18632/oncotarget.16444

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Abstract

Wenhua Xue1,*, Lifeng Li1,2,3,*, Xin Tian1,*, Zhirui Fan3, Ying Yue2,7, Chaoqi Zhang2,3, Xianfei Ding6, Xiaoqin Song4,5, Bingjun Ma1, Yunkai Zhai4,5, Jingli Lu1, Quancheng Kan1 and Jie Zhao1,4,5

1Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

2Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

3Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

4Engineering Research Center of Digital Medicine, Zhengzhou 450052, Henan, China

5Engineering Laboratory for Digital Telemedicine Service, Zhengzhou 450052, Henan, China

6Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China

7Department of Clinical Laboratory, The No.7. People’s Hospital in Zhengzhou, Zhengzhou 450016, Henan, China

*These authors have contributed equally to this work

Correspondence to:

Jie Zhao, email: [email protected]

Quancheng Kan, email: [email protected]

Keywords: lncRNAs, lung cancer, drug resistance, bioinformatics methods

Received: December 09, 2016    Accepted: February 28, 2017    Published: March 22, 2017

ABSTRACT

Lung cancer is one of the leading causes of cancer-related death. Resistance to chemotherapy and molecularly targeted therapies is a major problem that can contribute substantially to high mortality. The roles of long non-coding RNAs (lncRNAs) in drug resistance of lung cancer are insufficiently understood. Here, we identified a distinct drug resistance-related transcriptional signature and constructed a functional lncRNA-mRNA co-expression network. We found that 34 lncRNAs and 103 mRNAs have differential expression in drug resistance of lung cancer, in which 10 lncRNAs were down regulated and 24 up regulated; 49 mRNAs were down regulated and 54 up regulated. LncRNAs-mRNAs expression network analysis revealed a role for lncRNAs in modulating cancer-related pathways. We also found that two pair lncRNAs and their subnetworks were highly related to drug resistance. NR_028502.1/NR_028505.1 were found differentially co-expressed with nine mRNAs, and highly correlated with better clinical outcome. NR_030725.1/NR_030726.1 co-expressed with eleven mRNAs, and were associated with poor survival in patients with lung cancer. Our work comprehensively identified expression signature of resistance-associated lncRNAs and their inter-regulated mRNAs in lung cancer.


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