Integrated analysis profiles of long non-coding RNAs reveal potential biomarkers of drug resistance in lung cancer
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Wenhua Xue1,*, Lifeng Li1,2,3,*, Xin Tian1,*, Zhirui Fan3, Ying Yue2,7, Chaoqi Zhang2,3, Xianfei Ding6, Xiaoqin Song4,5, Bingjun Ma1, Yunkai Zhai4,5, Jingli Lu1, Quancheng Kan1 and Jie Zhao1,4,5
1Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
2Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
3Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
4Engineering Research Center of Digital Medicine, Zhengzhou 450052, Henan, China
5Engineering Laboratory for Digital Telemedicine Service, Zhengzhou 450052, Henan, China
6Department of General ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
7Department of Clinical Laboratory, The No.7. People’s Hospital in Zhengzhou, Zhengzhou 450016, Henan, China
*These authors have contributed equally to this work
Jie Zhao, email: [email protected]
Quancheng Kan, email: [email protected]
Keywords: lncRNAs, lung cancer, drug resistance, bioinformatics methods
Received: December 09, 2016 Accepted: February 28, 2017 Published: March 22, 2017
Lung cancer is one of the leading causes of cancer-related death. Resistance to chemotherapy and molecularly targeted therapies is a major problem that can contribute substantially to high mortality. The roles of long non-coding RNAs (lncRNAs) in drug resistance of lung cancer are insufficiently understood. Here, we identified a distinct drug resistance-related transcriptional signature and constructed a functional lncRNA-mRNA co-expression network. We found that 34 lncRNAs and 103 mRNAs have differential expression in drug resistance of lung cancer, in which 10 lncRNAs were down regulated and 24 up regulated; 49 mRNAs were down regulated and 54 up regulated. LncRNAs-mRNAs expression network analysis revealed a role for lncRNAs in modulating cancer-related pathways. We also found that two pair lncRNAs and their subnetworks were highly related to drug resistance. NR_028502.1/NR_028505.1 were found differentially co-expressed with nine mRNAs, and highly correlated with better clinical outcome. NR_030725.1/NR_030726.1 co-expressed with eleven mRNAs, and were associated with poor survival in patients with lung cancer. Our work comprehensively identified expression signature of resistance-associated lncRNAs and their inter-regulated mRNAs in lung cancer.
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