Research Papers:

The value of MRI in evaluating the efficacy and complications with the treatment of intra-arterial chemotherapy for retinoblastoma

Shuxian Chen, Xunda Ji, Ming Liu, Zhengrong Xia, Hui Zheng, Qiufeng Yin, He Wang and Yuhua Li _

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Oncotarget. 2017; 8:38413-38425. https://doi.org/10.18632/oncotarget.16423

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Shuxian Chen1,*, Xunda Ji2,*, Ming Liu1, Zhengrong Xia1, Hui Zheng1, Qiufeng Yin1, He Wang3, Yuhua Li1

1Department of Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

2Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

3Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China

*These authors have contributed equally to this work

Correspondence to:

Yuhua Li, email: [email protected]

He Wang, email: [email protected]

Keywords: retinoblastoma, intra-arterial chemotherapy, MRI, ADC value, children

Received: December 23, 2016     Accepted: March 14, 2017     Published: March 21, 2017


Retinoblastoma is the most common intraocular malignant tumor of childhood. Intra-arterial chemotherapy (IAC) is a recently popularized technique used for the treatment of retinoblastoma, to decrease mortality, increase preservation of the eye, and prevent blindness. Along with the extensive use of IAC, it is important to apply noninvasive examination methods to assess the activity of the tumor and the risk factors for disease dissemination without histopathological confirmation. There are few studies that have assessed the value of magnetic resonance imaging (MRI) in evaluating the efficacy and complications of IAC for retinoblastoma. We retrospectively analyzed the MRI features of 60 patients with unilateral retinoblastoma given the primary treatment of IAC from January 2014 to February 2016 in our hospital. Our study showed that MRI could well assess the decreased activity of the tumor after IAC, presenting with diminished tumor size, increased apparent diffusion coefficient (ADC) values (from 0.94 ± 0.24 × 10−3 mm2/s to 2.24 ± 0.40 × 10−3 mm2/s), and a reduced degree of enhancement of the tumor. Our study also showed that MRI can monitor the risk factors of abnormal enhancement of the postlaminar optic nerve, to avoid unnecessary enucleation. Meanwhile, the results showed that the main late complications after IAC included affected eyeball volume reduction, subretinal hemorrhage, vitreous hemorrhage, vitreous opacity, cataractous len, and choroidal vascular ischemia.

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