Oncotarget

Research Papers:

Prognostic roles of Notch receptor mRNA expression in human ovarian cancer

Chuan Chen, Xiaojiao Wang, Shunping Huang, Lin Wang, Lili Han and Songtao Yu _

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Oncotarget. 2017; 8:32731-32740. https://doi.org/10.18632/oncotarget.16387

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Abstract

Chuan Chen1,*, Xiaojiao Wang2,*, Shunping Huang3, Lin Wang4, Lili Han4, Songtao Yu2

1Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, P.R. China

2Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P. R. China

3Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P. R. China

4Department of Gynecology, People' s Hospital of Xinjiang Uyhgur Autonomous Region, Urumqi, Xinjiang 830001, P. R. China

*These authors contributed equally to this work

Correspondence to:

Songtao Yu, email: songtaoyu77@sina.com

Keywords: Notch receptor, mRNA expression, KM plotter, hazard ratio, prognosis

Received: September 01, 2016     Accepted: March 09, 2017     Published: March 20, 2017

ABSTRACT

Aberrant activation of Notch signaling pathway has been correlated with high grade ovarian carcinoma and carcinogenesis. However, the predictive and prognostic values of Notch signaling pathway in ovarian cancer patients remains unclear. We utilize “The Kaplan-Meier plotter” (KM plotter) background database to access the prognostic values including overall survival (OS), progression-free survival (PFS), as well as post-progression survival (PPS) of four Notch receptor mRNA expression in ovarian cancer patients. Notch1 mRNA high expression was not correlated with OS, PFS and PPS for all ovarian cancer patients, but significantly correlated with poor PFS in TP53 wild type and favorite PFS in TP53 mutation type ovarian cancer patients. Notch2 mRNA high expression was significantly correlated with poor PFS for all ovarian cancer patients, especially in grade II patients. Notch3 mRNA high expression was significantly correlated with favorite PFS for all ovarian cancer patients. Notch4 mRNA high expression was significantly correlated with favorite OS, but not PFS and PPS for all ovarian cancer patients. The results strongly support that there are distinct prognostic values of four Notch receptor mRNA expression in ovarian cancer patients.


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