Oncotarget

Research Papers:

Accumulation of myeloid-derived suppressor cells (MDSCs) induced by low levels of IL-6 correlates with poor prognosis in bladder cancer

Guoliang Yang, Wenyan Shen, Yan Zhang, Mengyao Liu, Lianhua Zhang, Qiang Liu, Hui Hui Lu and Juanjie Bo _

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Oncotarget. 2017; 8:38378-38388. https://doi.org/10.18632/oncotarget.16386

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Abstract

Guoliang Yang1,*, Wenyan Shen2,*, Yan Zhang3, Mengyao Liu4, Lianhua Zhang1, Qiang Liu5, Hui Hui Lu1, Juanjie Bo1

1Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

2Department of laboratory medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

3School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

4Clinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

5Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

*These authors contributed equally to this work

Correspondence to:

Juanjie Bo, email: bojuanjie@sina.com

Keywords: MDSCs, bladder cancer, IL-6, immune suppression, prognosis

Received: August 08, 2016     Accepted: February 27, 2017     Published: March 20, 2017

ABSTRACT

Bladder cancer (BC) is one of the most commonly occurring cancers, with a high recurrence rate and poor outcomes in cases of relapsed metastatic disease. Here, we analyzed the markers and significance of myeloid-derived suppressor cells (MDSCs) for BC development and progression. MDSC markers were examined in peripheral blood from 113 BC patients and 20 healthy volunteers. We identified CD11b+CD33lowHLA-DR CD3 cells as markers of MDSCs in peripheral blood from BC patients. We also demonstrated that MDSC numbers are higher in BC patients than healthy donors, and that MDSC numbers correlate with the clinical grade, stage, and poor prognosis. In addition, serum IL-6 levels are decreased in BC patients with higher MDSC counts. IL-6 blockade increases induction of MDSCs in vitro. Low IL-6 levels inhibit activation of Stat3, resulting in the increased formation of MDSCs in BC. These results indicate that the MDSCs numbers may serve as a novel prognostic marker in BC patients, and that targeting IL-6 signaling may be a promising strategy for BC treatment.


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