Accumulation of myeloid-derived suppressor cells (MDSCs) induced by low levels of IL-6 correlates with poor prognosis in bladder cancer
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Guoliang Yang1,*, Wenyan Shen2,*, Yan Zhang3, Mengyao Liu4, Lianhua Zhang1, Qiang Liu5, Hui Hui Lu1, Juanjie Bo1
1Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
2Department of laboratory medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
3School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
4Clinical Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
5Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
*These authors contributed equally to this work
Juanjie Bo, email: [email protected]
Keywords: MDSCs, bladder cancer, IL-6, immune suppression, prognosis
Received: August 08, 2016 Accepted: February 27, 2017 Published: March 20, 2017
Bladder cancer (BC) is one of the most commonly occurring cancers, with a high recurrence rate and poor outcomes in cases of relapsed metastatic disease. Here, we analyzed the markers and significance of myeloid-derived suppressor cells (MDSCs) for BC development and progression. MDSC markers were examined in peripheral blood from 113 BC patients and 20 healthy volunteers. We identified CD11b+CD33lowHLA-DR− CD3− cells as markers of MDSCs in peripheral blood from BC patients. We also demonstrated that MDSC numbers are higher in BC patients than healthy donors, and that MDSC numbers correlate with the clinical grade, stage, and poor prognosis. In addition, serum IL-6 levels are decreased in BC patients with higher MDSC counts. IL-6 blockade increases induction of MDSCs in vitro. Low IL-6 levels inhibit activation of Stat3, resulting in the increased formation of MDSCs in BC. These results indicate that the MDSCs numbers may serve as a novel prognostic marker in BC patients, and that targeting IL-6 signaling may be a promising strategy for BC treatment.
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