Clinical Research Papers:

Association between alcohol-induced osteonecrosis of femoral head and risk variants of MMPS in Han population based on a case-control study

Jianzhong Wang, Xugang Shi, Hua Yang, Jieli Du, Yongri Ouyang, Hong Wang, Tianbo Jin _ and Chao Chen

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Oncotarget. 2017; 8:64490-64498. https://doi.org/10.18632/oncotarget.16380

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Jianzhong Wang1,2, Xugang Shi3, Hua Yang3, Jieli Du2, Yongri Ouyang1, Hong Wang1, Tianbo Jin1,3 and Chao Chen1

1 National Engineering Research Center for Miniaturized Detection System, Northwest University, Xi’an, Shaanxi, China

2 Department of Orthopedics and Traumatology, The 2nd affiliated Hospital of Inner Mongolia University, Hohhot, Inner Mongolia, China

3 Xi’an Tiangen Precision Medical Research Institute, Xi’an, Shaanxi, China

Correspondence to:

Tianbo Jin, email:

Chao Chen, email:

Keywords: MMPs, alcohol-induced ONFH, SNPs, Han population

Received: September 07, 2016 Accepted: March 09, 2017 Published: March 18, 2017


The study aimed to evaluate the association between MMP gene superfamily and alcohol-induced osteonecrosis of femoral head (alcohol-induced ONFH) risk given its high prevalence, poor therapeutic effect, and serious clinical prognosis. 308 subjects (mean age, 49.47 years; males, 64.0%) who participated in our control group and 300 alcohol-induced ONFH patients (mean age, 43.29 years; males, 99.7%) formed the case group was enrolled to estimate by statistical analysis. We selected 23 single nucleotide polymorphisms (SNPs) from MMPs, and performed the chi-squared test, Fisher’s exact test, t-test and genetic model analyses. From the result, rs243849 which located in MMP2 were 1.355 (1.014-1.811), 1.34 (1.01-1.78) in allele model and log-addictive model, respectively. And the p-value of rs243849 in Cochran-Armitage trend test is 0.044. Unfortunately, the similar results of these SNPs were not observed when adjusted by gender and age. Our study is not enough to supply a positive result to benefit for alcohol-induced ONFH clinical prevention, but guide out a new direction for further experiment.

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