Oncotarget

Research Papers: Pathology:

Elevated serum level of pancreatic stone protein/regenerating protein (PSP/reg) is observed in diabetic kidney disease

Ling Li _, Dongyu Jia, Rolf Graf and Jiayue Yang

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Oncotarget. 2017; 8:38145-38151. https://doi.org/10.18632/oncotarget.16369

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Abstract

Ling Li1, Dongyu Jia2, Rolf Graf3,*and Jiayue Yang1,4,*

1 Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, Medical School, Southeast University, Dingjiaqiao, Nanjing, PR China

2 Women’s Cancer Program, Cedars-Sinai Medical Center, Beverly Boulevard, Los Angeles, CA, USA

3 Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Rämistrasse, Zurich, Switzerland

4 Department of Internal Medicine, Division of Diabetes, Metabolism and Endocrinology, Nanjing Medical University Affiliated Wuxi People’s Hospital, Wuxi, PR China

* These authors have contributed equally to this work

Correspondence to:

Rolf Graf, email:

Jiayue Yang, email:

Keywords: pancreatic stone protein, type 2 diabetes mellitus, diabetic kidney disease, inflammation, serum parameters, Pathology Section

Received: November 11, 2016 Accepted: February 27, 2017 Published: March 18, 2017

Abstract

Diabetic kidney disease (DKD) is a major complication of diabetes, and serves as an important cause of end-stage renal disease (ESRD). The role of chronic inflammation in DKD is becoming widely accepted. Pancreatic stone protein/regenerating protein (PSP/reg) is a secretory protein, which is elevated in blood during infected conditions and organ failure. The aim of this study was to investigate the relationship between serum PSP/reg and DKD in patients with type 2 diabetes (T2DM). A total of 120 subjects which includes newly diagnosed T2DM patients, diabetes patients without DKD, DKD patients, as well as healthy controls were enrolled in this study. Serum PSP/reg levels were significantly higher in DKD subjects compared with those of healthy controls (p < 0.001), newly diagnosed T2DM (p < 0.001) and diabetes patients without DKD (p < 0.001). PSP/reg levels correlated positively with glycated hemoglobin (HbA1c) (p < 0.001) and serum creatinine (p < 0.001). Meanwhile, serum PSP level was negatively correlated with estimated glomerular filtration rate (eGFR) (p < 0.001). The area under the curve (AUC) for presence of DKD was 0.854. In conclusion: PSP/reg levels are significantly up-regulated in DKD patients and might be related to renal injury. A follow-up study with a large cohort is needed.


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