Research Papers:

Influence of marital status on the survival of adults with extrahepatic/intrahepatic cholangiocarcinoma

Zhiqiang Chen, Liyong Pu, Wen Gao, Long Zhang, Guoyong Han, Qin Zhu, Xiangcheng Li, Jindao Wu and Xuehao Wang _

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Oncotarget. 2017; 8:28959-28970. https://doi.org/10.18632/oncotarget.16330

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Zhiqiang Chen1,*, Liyong Pu1,*, Wen Gao2,*, Long Zhang1, Guoyong Han1, Qin Zhu1, Xiangcheng Li1, Jindao Wu1, Xuehao Wang1

1Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory on Living Donor Liver Transplantation, National Health and Family Planning Commission, Nanjing, Jiangsu Province, China

2Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China

*These authors contributed equally to this work

Correspondence to:

Xuehao Wang, email: wangxh@njmu.edu.cn

Jindao Wu, email: wujindao@njmu.edu.cn

Xiangcheng Li, email: drxcli@njmu.edu.cn

Keywords: cholangiocarcinoma, marital status, SEER, survival analysis, prognosis

Received: December 08, 2016     Accepted: February 28, 2017     Published: March 17, 2017


Although the prognostic value of marital status has been implicated in many cancers, its prognostic impact on cholangiocarcinoma has not yet been determined. The aim of this study was to examine the association between marital status and cholangiocarcinoma survival. We included 8,776 extrahepatic cholangiocarcinoma cases and 1,352 intrahepatic cholangiocarcinoma cases between 1973 and 2013 from the Surveillance, Epidemiology, and End Results database. We found widowed patients were more likely to be female, aged more than 70, and from low income areas. Multivariate analysis indicated that marital status was an independent prognostic factor for extrahepatic cholangiocarcinoma patients. Subgroup analysis suggested the widowed status independently predicted poor survival at regional stage and in older patients with intrahepatic cholangiocarcinoma. To conclude, marital status is a valuable prognostic factor in cholangiocarcinoma, and widowed patients are at greater risk of death than others.

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