Oncotarget

Research Papers:

The miR-124-p63 feedback loop modulates colorectal cancer growth

Kuijie Liu, Hongliang Yao, Sanlin Lei, Li Xiong, Haizhi Qi, Ke Qian, Jiqiang Liu, Peng Wang and Hua Zhao _

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Oncotarget. 2017; 8:29101-29115. https://doi.org/10.18632/oncotarget.16248

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Abstract

Kuijie Liu1, Hongliang Yao1, Sanlin Lei1, Li Xiong1, Haizhi Qi1, Ke Qian1, Jiqiang Liu1, Peng Wang1, Hua Zhao1

1Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha 410011, China

Correspondence to:

Hua Zhao, email: drzhaohua2012@163.com

Keywords: miR-124, p63, feedback loop, cell growth, colorectal cancer

Received: May 26, 2016     Accepted: February 20, 2017     Published: March 16, 2017

ABSTRACT

Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ΔNp63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124. Taken together, these results reveal a feedback loop between miRNAs and TFs. This feedback loop comprises miR-124, iASPP, STAT1, miR-155, TAp63 and ΔNp63, which are essential for CRC growth. Moreover, this feedback loop is perturbed in human colon carcinomas, which suggests that the manipulation of this microRNA-TF feedback loop has therapeutic potential for CRC.


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