Oncotarget

Clinical Research Papers:

The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer

Chiyao Hsueh, Lei Tao, Ming Zhang, Wenjun Cao, Hongli Gong, Jian Zhou and Liang Zhou _

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Oncotarget. 2017; 8:60514-60527. https://doi.org/10.18632/oncotarget.16234

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Abstract

Chiyao Hsueh1,2, Lei Tao1,2, Ming Zhang1,2, Wenjun Cao3, Hongli Gong1,2, Jian Zhou1,2 and Liang Zhou1,2

1 Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, PR China

2 Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China

3 Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, PR China

Correspondence to:

Liang Zhou, email:

Keywords: lymphocytes, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, laryngeal squamous carcinoma, prognosis

Received: December 27, 2016 Accepted: February 20, 2017 Published: March 15, 2017

Abstract

This study was aimed to examine the prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer (LSCC). From January 2007 to December 2011, 979 patients with LSCC were enrolled in our study. Preoperative neutrophils, platelets, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were analyzed. Besides well-established clinicopathological prognostic factors, we evaluated the independent prognostic relevance of these hematological parameters by Cox regression models in disease-free survival (DFS) and cancer-specific survival (CSS). We found patients in the highest tertile of NLR (>2.40), PLR (>111.00) were at significantly higher risk of DFS and CSS (P<0.05) compared with those in the lowest tertile after multivariate analysis, whereas presenting significantly higher risk in the lowest tertile of lymphocytes (<1.60×109/L) and LMR (<3.50). Additionally, the tertile category of NLR as well as PLR increased and lymphocytes as well as LMR decreased in shorter DFS and CSS by the Kaplan-Meier method and the log-rank test. In conclusion, this study indicated that preoperative lymphocytes, NLR, PLR and LMR were significantly associated with LSCC progression, DFS and CSS, and these hematological parameters could be considered independent prognostic values for patients with LSCC.


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