Research Papers:

Quercetin delays postovulatory aging of mouse oocytes by regulating SIRT expression and MPF activity

HaiYang Wang _, Yu-Jin Jo, Jeong Su Oh and Nam-Hyung Kim

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Oncotarget. 2017; 8:38631-38641. https://doi.org/10.18632/oncotarget.16219

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HaiYang Wang1, Yu-Jin Jo1, Jeong Su Oh2 and Nam-Hyung Kim1

1Department of Animal Sciences, Chungbuk National University, Cheongju, Korea

2Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Korea

Correspondence to:

Jeong Su Oh, email: [email protected]

Nam-Hyung Kim, email: [email protected]

Keywords: MPF, oocyte, postovulatory aging, quercetin, SIRT

Received: November 08, 2016    Accepted: February 20, 2017    Published: March 15, 2017


If no fertilization occurs at an appropriate time after ovulation, oocyte quality deteriorates rapidly as a process called postovulatory aging. Because the postovulatory aging of oocytes has detrimental effects on embryo development and offspring, many efforts have been made to prevent oocyte aging. Here we showed that quercetin prevented the decline in oocyte quality during postovulatory aging of oocytes. Quercetin treatment reduced aging-induced morphological changes and reactive oxygen species accumulation. Moreover, quercetin attenuated the aging-associated abnormalities in spindle organization and mitochondrial distribution, preventing decrease of SIRT expression and histone methylation. Quercetin also ameliorated the decrease in maturation-promoting factor activity and the onset of apoptosis during postovulatory aging. Furthermore, quercetin treatment during postovulatory aging improves early embryo development. Our results demonstrate that quercetin relieves deterioration in oocyte quality and improves subsequent embryo development.

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