Oncotarget

Research Papers:

Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma

Hao Song, Lizhen Wang, Jiong Lyu, Yunteng Wu, Wei Guo _ and Guoxin Ren

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Oncotarget. 2017; 8:29080-29090. https://doi.org/10.18632/oncotarget.16175

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Abstract

Hao Song1, Lizhen Wang2, Jiong Lyu3, Yunteng Wu1, Wei Guo1, Guoxin Ren1

1Department of Oral & Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China

2Department of Oral Pathology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China

3Department of Stomatology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang Province, 310003, China

Correspondence to:

Wei Guo, email: guoweicn@yahoo.com

Guoxin Ren, email: renguoxincn@hotmail.com

Keywords: oral mucosa, melanoma, BAP1, prognosis, immunohistochemistry

Received: October 04, 2016    Accepted: January 10, 2017    Published: March 14, 2017

ABSTRACT

Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. DNA sequence analysis of BAP1 from 12 OMM patient samples revealed missense mutations in the tissues from four patients. Based on immunohistochemical staining, loss of nuclear BAP1 expression was associated with poor overall survival (P < 0.001, Log-rank = 21.308) and distant metastasis (P = 0.034, OR = 0.320). Multivariate analysis showed BAP1 to be an independent prognostic factor (P = 0.027, HR = 0.479). It thus appears that loss of nuclear BAP1 expression is an independent prognostic factor of poor overall survival and associated with distant metastasis in OMM.


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