Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma
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Hao Song1, Lizhen Wang2, Jiong Lyu3, Yunteng Wu1, Wei Guo1, Guoxin Ren1
1Department of Oral & Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China
2Department of Oral Pathology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200011, China
3Department of Stomatology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang Province, 310003, China
Wei Guo, email: email@example.com
Guoxin Ren, email: firstname.lastname@example.org
Keywords: oral mucosa, melanoma, BAP1, prognosis, immunohistochemistry
Received: October 04, 2016 Accepted: January 10, 2017 Published: March 14, 2017
Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. DNA sequence analysis of BAP1 from 12 OMM patient samples revealed missense mutations in the tissues from four patients. Based on immunohistochemical staining, loss of nuclear BAP1 expression was associated with poor overall survival (P < 0.001, Log-rank = 21.308) and distant metastasis (P = 0.034, OR = 0.320). Multivariate analysis showed BAP1 to be an independent prognostic factor (P = 0.027, HR = 0.479). It thus appears that loss of nuclear BAP1 expression is an independent prognostic factor of poor overall survival and associated with distant metastasis in OMM.
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