Oncotarget

Research Papers:

GATA3 and TRPS1 are distinct biomarkers and prognostic factors in breast cancer: database mining for GATA family members in malignancies

Hao-Yu Lin _, De Zeng, Yuan-Ke Liang, Xiao-Long Wei and Chun-Fa Chen

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Oncotarget. 2017; 8:34750-34761. https://doi.org/10.18632/oncotarget.16160

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Abstract

Hao-Yu Lin1,*, De Zeng2,3,*, Yuan-Ke Liang3,4, Xiao-Long Wei5 and Chun-Fa Chen1

1Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China

2Department of Breast Medical Oncology, Cancer Hospital of Shantou University Medical College, Shantou, China

3ChangJiang Scholar’s Laboratory of Shantou University Medical College, Shantou, China

4Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

5Department of Pathology, Cancer Hospital of SUMC, Shantou, China

*These authors have contributed equally to this work

Correspondence to:

Hao-yu Lin, email: Rainlhy@stu.edu.cn

Keywords: GATA, breast cancer, database mining, prognostic values, chemosensitivity

Received: January 10, 2017    Accepted: February 13, 2017    Published: March 13, 2017

ABSTRACT

GATA transcription factors are zinc finger DNA binding proteins that activate transcription during development and cell differentiation. To date, 7 members of GATA family have been reported. However, the expression patterns and the exact roles of distinct GATA family members contributing to tumorigenesis and progression of breast cancer (BC) remain to be elucidated. Here, we studied the expression of GATA transcripts in a variety of tumor types compared with the normal controls using the ONCOMINE and GOBO databases, along with their corresponding expression profiles in an array of cancer cell lines through CCLE analysis. Based on Kaplan-Meier plotter, we further investigated the prognostic values of GATA members specifically high expressed in BC patients. It was found that, when compared with normal tissues, GATA3 and TRPS1 were distinctly high expressed in BC patients among all GATA members. GATA3 expression was significantly associated with ESR1, while TRPS1 was correlated with ERBB2. In survival analysis, GATA3 and TRPS1 mRNA high expressions were correlated to better survival in BC patients, and TRPS1 high expression was significantly associated with longer RFS in patients who have received chemotherapy. These results suggest that GATA3 and TRPS1 are distinct biomarkers and essential prognostic factors for breast cancer.


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