Research Papers: Gerotarget (Focus on Aging):
Examining the association between anthropometric parameters and telomere length and mortality risk
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Chen-Jung Wu1,2, Tung-Wei Kao1,3,4, Yuan-Yung Lin5,6, Fang-Yih Liaw1,3, Li-Wei Wu1,3, Yaw-Wen Chang1,3, Tao-Chun Peng1,3 and Wei-Liang Chen1,3,6
1 Department of Family and Community Medicine, Division of Family Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
2 Department of Community Medicine, Division of Family Medicine, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, Republic of China
3 Department of Family and Community Medicine, Division of Geriatric Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
4 Graduate Institute of Clinical Medical, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
5 Department of Otolaryngology–Head and Neck Surgery, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China
6 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
Wei-Liang Chen, email:
Keywords: anthropometric indices; telomere length; mortality risk; Gerotarget
Received: December 02, 2016 Accepted: February 28, 2017 Published: March 07, 2017
A shorter telomere length is associated with several systemic disorders. Telomere length may be an informative biomarker for the maintenance of the overall health status and mortality. There are a limited number of empirical studies concerning the effect of anthropometric parameters on telomere length. The data are derived from the National Health and Nutrition Examination Survey from 1999 to 2002. The primary outcomes of this study were to examine the potential relationships between the anthropometric indices and the telomere length, while secondary outcomes of this study was to investigate the association between different anthropometric indices and mortality risk. A significant positive correlation was noted between the mean telomere length and the thigh circumference (TC) and calf circumference (CC) in all designed models. Participants in the highest TC and CC quartiles tended to have a longer telomere length and lowered the hazards for all-cause mortality to 43% and 57%, respectively. Notably, the anthropometric indices involving the CC with higher values seemed to be surrogate markers for the reduction of the risk of all-cause, cardiovascular and malignancy-related mortality (all P < 0.05). The CCmay be a valuable tool to guide public health policy and a clinical prognostic indicator for the risk of mortality.
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