Prognostic role of matrix metalloproteinases in bladder carcinoma: a systematic review and meta-analysis

Chenkui Miao, Chao Liang, Jundong Zhu, Aiming Xu, Kai Zhao, Yibo Hua, Jianzhong Zhang, Wei Chen, Chuanjian Suo, Chao Zhang, Yiyang Liu, Shifeng Su and Zengjun Wang _

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Oncotarget. 2017; 8:32309-32321. https://doi.org/10.18632/oncotarget.15907

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Chenkui Miao1,*, Chao Liang1,*, Jundong Zhu1,*, Aiming Xu1, Kai Zhao1, Yibo Hua1, Jianzhong Zhang1, Wei Chen2, Chuanjian Suo1, Chao Zhang1, Yiyang Liu1, Shifeng Su1 and Zengjun Wang1

1 State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China

2 Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China

* These authors have contributed equally to this work

Correspondence to:

Zengjun Wang, email:

Shifeng Su, email:

Keywords: matrix metalloproteinases, bladder cancer, prognosis, meta-analysis

Received: September 06, 2016 Accepted: February 21, 2017 Published: March 04, 2017


Recent studies have shown that matrix metalloproteinases (MMPs) might be a biomarker for predicting outcomes of bladder cancer. However, the prognostic value of overexpression of MMPs in bladder cancer is debatable and the studies are inconsistent. Therefore, this meta-analysis was performed to clarify the specific association and prognostic value of overexpression of MMPs in bladder carcinoma. Relevant studies were identified by searching PubMed, EMBASE, and the Web of Science. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for disease-specific survival (DSS), overall survival (OS), disease/recurrence-free survival (DFS/RFS), and progression/metastasis-free survival (PFS/MFS) were analyzed to determine the prognostic value of MMPs. In total, eighteen applicable studies were included in this meta-analysis. We found that high expression of MMPs significantly correlated with a poor DSS and OS (HR=1.66; 95% CI = 1.38–2.01 and HR= 1.67; 95%CI= 1.26–2.22). MMPs also predicted tumor progression and metastasis with a pooled HR of 3.03 (95% CI 1.98–4.64). However, high MMPs expression had no pivotal impact on DFS/RFS (HR= 1.21; 95% CI= 0.96–1.53). With the purpose of better understanding the prognostic role of MMPs in patients wirh bladder carcinoma, we carried out this systematic review and meta-analysis.

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