Oncotarget

Research Papers:

Regional structural impairments outside lesions are associated with verbal short-term memory deficits in chronic subcortical stroke

Qingqing Diao, Jingchun Liu, Caihong Wang, Jingliang Cheng, Tong Han and Xuejun Zhang _

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Oncotarget. 2017; 8:30900-30907. https://doi.org/10.18632/oncotarget.15882

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Abstract

Qingqing Diao1, Jingchun Liu1, Caihong Wang2, Jingliang Cheng2, Tong Han3, Xuejun Zhang4

1Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China

2Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

3Department of Radiology, Tianjin Huanhu Hospital, Tianjin 300350, China

4School of Medical Imaging, Tianjin Medical University, Tianjin 300070, China

Correspondence to:

Xuejun Zhang, email: ydzhangxj@126.com

Keywords: ischemic stroke, verbal short-term memory, grey matter volume, voxel-based lesion symptom mapping

Received: October 11, 2016     Accepted: February 21, 2017     Published: March 03, 2017

ABSTRACT

Background and Purpose: We aimed to explore the neural mechanisms of verbal short-term memory (VSTM) impairment in subcortical stroke by evaluating the contributions of lesion and remote grey matter volume (GMV) reduction.

Results: There was no significant correlation between lesions and VSTM. In stroke patients with left lesions, GMV reductions in the right middle frontal gyrus and in the left inferior frontal gyrus were positively correlated with VSTM impairment. In patients with right lesions, GMV reduction in the right dorsal posterior cingulate cortex was positively correlated with VSTM impairment.

Materials and Methods: Ninety-seven patients with chronic subcortical ischemic stroke and seventy-nine healthy controls underwent VSTM and structural MRI examinations. Voxel-based lesion symptom mapping was used to identify correlations between lesions and VSTM. Voxel-wise comparisons were used to identify brain regions with significant GMV reduction in patients with left and right lesions. These regions were used in correlation analyses between GMV and VSTM in each patient subgroup.

Conclusions: These findings suggest that VSTM impairment in subcortical stroke is associated with secondary regional structural damage in non-lesion regions, rather than with the lesion itself. Moreover, different neural substrates may underlie VSTM impairment in stroke patients with left and right lesions.


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