Oncotarget

Research Papers:

TCF7L2 polymorphisms and the risk of schizophrenia in the Chinese Han population

Lijun Liu, Jingjie Li, Mengdan Yan, Jing Li, Junyu Chen, Yi Zhang, Xikai Zhu, Li Wang, Longli Kang, Dongya Yuan _ and Tianbo Jin

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Oncotarget. 2017; 8:28614-28620. https://doi.org/10.18632/oncotarget.15603

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Abstract

Lijun Liu1,2,3, Jingjie Li4, Mengdan Yan4, Jing Li4, Junyu Chen5, Yi Zhang5, Xikai Zhu1,2,3, Li Wang1,2,3, Longli Kang1,2,3, Dongya Yuan1,2,3, Tianbo Jin1,2,3,4

1Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China

2Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China

3Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China

4Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, China

5Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China

Correspondence to:

Dongya Yuan, email: dongyayuanxzmz@gmail.com

Tianbo Jin, email: jintianbo@gmail.com

Keywords: TCF7L2, schizophrenia, SNP, case-control

Received: September 06, 2016    Accepted: January 04, 2017    Published: February 22, 2017

ABSTRACT

Single nucleotide polymorphisms (SNPs) in TCF7L2 (Transcription Factor 7-Like 2) reportedly affect susceptibility to schizophrenia (SCZ). We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. Six SNPs were genotyped in 499 SCZ patients and 500 healthy individuals, after which their associations with SCZ were evaluated using the Chi-squared test and genetic model analyses. We observed that the allele A of rs12573128 is associated with an increased SCZ risk (odds ratio [OR] = 1.33, 95% confidence interval [CI]: 1.08-1.63, P = 0.006, adjusted P = 0.030). The AA genotype of rs12573128 was associated with a higher SCZ risk than the GG genotype, before and after adjustment for sex and age (adjusted OR = 2.97, 95% CI: 1.49-5.92, P = 0.002). In addition, SNP rs12573128 was associated with 1.47-fold, 2.64-fold and 1.50-fold increases in SCZ risk of in dominant, recessive and additive model, respectively (adjusted OR = 1.47, 95% CI = 1.09-1.99, P = 0.012; Bonferroni adjusted P = 0.030). adjusted OR = 2.64, 95% CI = 1.34-5.18, P = 0.005 and adjusted OR = 1.50, 95% CI = 1.17-1.93, P = 0.002, respectively). These results suggest rs12573128 is significantly associated with an increased risk of SCZ in the Chinese Han population.


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