Research Papers:

Systematic review with network meta-analysis: comparative efficacy of different enteral immunonutrition formulas in patients underwent gastrectomy

Guo-Min Song, Xiao-Ling Liu, Wei Bian, Jing Wu, Yong-Hong Deng, Hui Zhang and Xu Tian _

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Oncotarget. 2017; 8:23376-23388. https://doi.org/10.18632/oncotarget.15580

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Guo-Min Song1,*, Xiao-Ling Liu2,*, Wei Bian3,*, Jing Wu2,*, Yong-Hong Deng4, Hui Zhang4, Xu Tian2

1Department of Nursing, Tianjin Hospital, Tianjin 300211, China

2Department of Gastroenterology, Chongqing Cancer Institute and Hospital and Cancer Center, Chongqing 400030, China

3Ophthalmology Department, Southwest Hospital, Third Military Medical University, Chongqing 400031, China

4Graduate College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

*These authors contributed equally to this work

Correspondence to:

Xu Tian, email: [email protected]

Keywords: stomach neoplasm, surgical resection, enteral nutrition, immunonutrition, meta-analysis

Received: June 11, 2016     Accepted: February 10, 2017     Published: February 21, 2017


Objectives: Optimal enteral immunonutrition (EIN) regime for gastric cancer (GC) patients underwent gastrectomy remains uncertainty. To assess comparative efficacy of different EIN formulas in GC patients underwent gastrectomy, we performed network meta-analysis.

Results: We included 11 RCTs enrolling 840 patients. Pairwise meta-analysis indicated that EIN (RR 0.56, 95% CI 0.36-0.86; MD -0.42, 95% CI -0.74—0.10), Arg+RNA+ω-3-FAs (RR 0.37, 95% CI 0.22-0.63; MD -0.42, 95% CI -0.75—0.07), Arg+Gln+ω-3-FAs (RR 0.22, 95% CI 0.05-0.94; MD -0.69, 95% CI -1.22—1.07) reduced ICs and LOS. Network meta-analysis confirmed the potential of Arg+RNA+ω-3-FAs for ICs (OR 0.27, 95% Crl 0.12–0.49) and Arg+Gln+ω-3-FAs for CIs (OR 0.22, 95% Crl 0.02–0.84) and LOS (SMD -0.63, 95% Crl -1.07—0.13), and indicated that Arg+RNA+ω-3-FAs was superior to Arg+RNA and Arg+Gln for ICs as well.

Materials and Methods: We performed direct and network meta-analyses for randomized controlled trials comparing EIN formulas with each other or standard enteral nutrition (SEN) in reducing infectious complications (ICs), noninfectious complications (NICs) and length of hospital stay (LOS), through January 2016. The surface under the cumulative ranking curve (SCURA) and Grading of Recommendations Assessment, Development and Evaluation (GRADE) were used to rank regimes and rate qualities of evidences respectively.

Conclusions: As for GC patients underwent gastrectomy, Arg+RNA+ω-3-FAs and Arg+Gln+ω-3-FAs are the optimal regimes of reducing ICs and LOS.

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