Membranous nephropathy associated with hepatitis C virus infection treated with corticosteroids and Ledipasvir-Sofosbuvir: a case report and review of literature
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Qinjie Weng1, Xiao Li1, Hong Ren1, Jingyuan Xie1, Xiaoxia Pan1, Jing Xu1 and Nan Chen1
1 Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Nan Chen, email:
Keywords: hepatitis C virus, membranous nephropathy, hepatitis C virus-related glomerulonephritis, Ledipasvir-Sofosbuvir, case report
Received: October 02, 2016 Accepted: January 25, 2017 Published: February 16, 2017
Background: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. As many clinical cases have reported, it may be associated with hepatitis C virus (HCV) infection. Antiviral therapy can be various.
Case summary: We report a case of patient with chronic HCV infection and MN, who presented with was proteinuria. He was treated with ledipasvir and sofosbuvir (Harvoni; Gilead Sciences, Foster City, CA) and was found to be virus-free.
Conclusion: We have reported this case to provide insight into whether Ledipasvir-Sofosbuvir should be administered for HCV-related glomerulonephritis.
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