Oncotarget

Clinical Research Papers:

Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis

Yang Wu, Zi-Peng Lu, Jing-Jing Zhang, Dong-Fang Liu, Guo-Dong Shi, Chun Zhang, Zhi-Qiang Qin, Jian-Zhong Zhang, Yuan He, Peng-Fei Wu, Yi Miao and Kui-Rong Jiang _

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Oncotarget. 2017; 8:50124-50132. https://doi.org/10.18632/oncotarget.15394

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Abstract

Yang Wu1,2,*, Zi-Peng Lu1,2,*, Jing-Jing Zhang1,2,*, Dong-Fang Liu1,2, Guo-Dong Shi1,2, Chun Zhang3, Zhi-Qiang Qin4, Jian-Zhong Zhang4, Yuan He2,5, Peng-Fei Wu1,2, Yi Miao1,2 and Kui-Rong Jiang1,2

1 Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

2 Pancreas Institute, Nanjing Medical University, Nanjing, China

3 Department of Digestive Diseases, Songjiang Branch Hospital of Shanghai First People’s Hospital, Nanjing Medical University, Shanghai, China

4 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

5 Department of Gastrointestinal Surgery, Huai’an Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, Huai’an, China

* These authors have contributed equally to this work

Correspondence to:

Kui-Rong Jiang, email:

Keywords: pancreatic cancer; ERCC2; rs13181; polymorphism; meta-analysis

Received: August 15, 2016 Accepted: January 29, 2017 Published: February 16, 2017

Abstract

Single nucleotide polymorphisms (SNPs) of Excision repair cross-complementing group 2 (ERCC2) gene are suspected to affect the risk of pancreatic cancer. Many studies have reported the association between ERCC2 Lys751Gln polymorphism (rs13181) and the susceptibility to pancreatic cancer, but the outcomes remained controversial. To comprehensively determine this association, we conducted a meta-analysis based on a total of eight studies. Evidence for this association was obtained from the PubMed, EMBASE, Web of Science and Chinese National Knowledge Infrastructure (CNKI) databases. In general, a significant association was found between ERCC2 rs13181 polymorphism and the susceptibility to pancreatic cancer in four genetic models [CC vs. AA: OR = 1.56, (95% CI: 1.28-1.90), P = 0.470; AC/CC vs. AA: OR=1.20, (95% CI: 1.06-1.36), P = 0.396; CC vs. AC/CC: OR = 1.50; (95% CI: 1.24-1.81), P = 0.530; C vs. A: OR=1.22, (95%CI:1.11-1.34), P = 0.159]. Furthermore, stratified analyses by ethnicity indicated a significant association only in the Asian population. Our results indicate that the ERCC2 Lys751Gln polymorphism might be important in stimulating the development of pancreatic cancer, especially for Asians.


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