Research Papers:

Altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional MR imaging study with granger causality analysis

Li Juan Zheng, Gui Fen Yang, Xin Yuan Zhang, Yun Fei Wang, Ya Liu, Gang Zheng, Guang Ming Lu, Long Jiang Zhang and Ying Han _

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Oncotarget. 2017; 8:25021-25031. https://doi.org/10.18632/oncotarget.15335

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Li Juan Zheng1,*, Gui Fen Yang1,*, Xin Yuan Zhang1, Yun Fei Wang1, Ya Liu2, Gang Zheng1,2, Guang Ming Lu1, Long Jiang Zhang1, Ying Han3,4

1Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China

2College of Civil Aviation, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, 210016, China

3Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China

4Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

*These authors have contributed equally to this work

Correspondence to:

Ying Han, email: [email protected]

Long Jiang Zhang, email: [email protected]

Keywords: major depression disorder, amnestic cognitive impairment, granger causality analysis, amygdala, hippocampus

Received: October 21, 2016     Accepted: January 09, 2017     Published: February 15, 2017


Neuroimaging studies have demonstrated that the major depression disorder would increase the risk of dementia in the older with amnestic cognitive impairment. We used granger causality analysis algorithm to explore the amygdala- and hippocampus-based directional connectivity patterns in 12 patients with major depression disorder and amnestic cognitive impairment (mean age: 69.5 ± 10.3 years), 13 amnestic cognitive impairment patients (mean age: 72.7 ± 8.5 years) and 14 healthy controls (mean age: 64.7 ± 7.0 years). Compared with amnestic cognitive impairment patients and control groups respectively, the patients with both major depression disorder and amnestic cognitive impairment displayed increased effective connectivity from the right amygdala to the right lingual and calcarine gyrus, as well as to the bilateral supplementary motor areas. Meanwhile, the patients with both major depression disorder and amnestic cognitive impairment had enhanced effective connectivity from the left superior parietal gyrus, superior and middle occipital gyrus to the left hippocampus, the z values of which was also correlated with the scores of mini-mental state examination and auditory verbal learning test-immediate recall. Our findings indicated that the directional effective connectivity of right amygdala - occipital-parietal lobe – left hippocampus might be the pathway by which major depression disorder inhibited the brain activity in patients with amnestic cognitive impairment.

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