Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis
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Nan Shen1,*, Yuan Ruan2,*,#, Yajun Lu3, Xuefeng Jiang4, Huiqing Sun4, Gongming Gao5, Luming Nong5, Kewei Ren4
1Department of Clinical Pharmacy, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China
2Department of Minimally Invasive Spine Center, Renji Orthopedics Hospital, Shantou 515065, China
3Department of Orthopedics, Jiangyin No 3 People’s Hospital, Jiangyin 214433, China
4Department of Orthopedics, The Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China
5Department of Orthopedics, The Affiliated Changzhou No 2 Hospital of Nanjing Medical University, Changzhou 213003, China
*These authors have contributed equally to this work
Luming Nong, email: [email protected]
Kewei Ren, email: [email protected]
Keywords: TNFAIP3, single nucleotide polymorphism, rheumatoid arthritis, meta-analysis
Received: December 30, 2016 Accepted: January 25, 2017 Published: February 10, 2017
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic destructive inflammation in synovial joints. To date, many studies explored the associations between tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs6920220, rs2230926, and rs5029937 polymorphisms and the risk of rheumatoid arthritis (RA), but with contradictory results. We therefore conducted a comprehensive meta-analysis to address the associations. We searched in the databases of PubMed and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the Stata 11.0 software. A total of 21 case-control studies for these three single nucleotide polymorphisms (SNPs) were included in this meta-analysis. Meta-analysis indicated that TNFAIP3 gene rs6920220, rs2230926, and rs5029937 polymorphisms were associated with the increased risk of RA. Stratification analysis of ethnicity found that rs6920220 and rs5029937 polymorphisms increased the risk of RA among Caucasians, while rs2230926 polymorphism increased the risk of RA among Asians. In summary, this meta-analysis confirms that TNFAIP3 gene polymorphisms may play important roles in the pathogenesis of RA.
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