MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1

Anfei Huang; Yi Yang; Si Chen; Fei Xia; Di Sun; Deyu Fang; Sidong Xiong; Liping Jin; Jinping Zhang

doi:10.18632/oncotarget.15228

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1

Anfei Huang _, Yi Yang, Si Chen, Fei Xia, Di Sun, Deyu Fang, Sidong Xiong, Liping Jin and Jinping Zhang

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2017; 8:17191-17201. https://doi.org/10.18632/oncotarget.15228

Metrics: PDF 1872 views | HTML 2235 views | ?

Abstract

Anfei Huang1,*, Yi Yang1,*, Si Chen1, Fei Xia1, Di Sun1, Deyu Fang2, Sidong Xiong1, Liping Jin3, Jinping Zhang1

1Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, People’s Republic of China

2Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

3Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, China

*These authors have contributed equally to the work

Correspondence to:

Jinping Zhang, email: [email protected]

Liping Jin, email: [email protected]

Keywords: miR-34a, cDCs, development, IL-17a, T cell activation

Received: July 07, 2016 Accepted: January 16, 2017 Published: February 09, 2017

ABSTRACT

MicroRNAs serve important functions in numerous biological processes. Whether microRNAs also act on dendritic cell (DC) differentiation and function remains unclear. In this study, both conventional DCs (cDCs) and plasmacytoid DCs (pDCs) were increased in miR-34a overexpressing bone marrow chimeric and transgenic (TG) mice. Further experiments showed that miR-34a promoted preDC differentiated into cDCs and pDCs without affecting the proliferation and apoptosis of DCs. Luciferase report assay and Western blot experiments demonstrated that WNT1 is the direct target of miR-34a in DCs. Interestingly, miR-34a overexpressing cDCs also produced a large amount of IL-17a and suppressed T cell activation because of the inhibition of TCF1 expression, thus increasing RORγT expression. Taken together, miR-34a promotes preDC to differentiate into cDCs and pDCs, as well as inhibits the function of cDCs on the activation of CD4⁺ T cells by producing IL-17a.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 15228

Publication Alerts

Research Papers:

MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1

Abstract