Oncotarget

Research Papers:

Whole-genome sequencing identifies new genetic alterations in meningiomas

Mei Tang, Heng Wei, Lu Han, Jiaojiao Deng, Yuelong Wang, Meijia Yang, Yani Tang, Gang Guo, Liangxue Zhou and Aiping Tong _

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:17070-17080. https://doi.org/10.18632/oncotarget.15043

Metrics: PDF 1071 views  |   HTML 1307 views  |   ?  


Abstract

Mei Tang1,*, Heng Wei2,*, Lu Han1,*, Jiaojiao Deng3, Yuelong Wang3, Meijia Yang1, Yani Tang1, Gang Guo1, Liangxue Zhou3, Aiping Tong1

1The State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

2College of Life Science, Sichuan University, Chengdu 610064, China

3Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

*These authors have contributed equally to the work

Correspondence to:

Aiping Tong, email: aipingtong@scu.edu.cn

Liangxue Zhou, email: liangxue_zhou@126.com

Keywords: whole-genome sequencing, meningioma, chromosome instability, copy number alteration, mutation

Received: October 24, 2016    Accepted: January 13, 2017    Published: February 03, 2017

ABSTRACT

The major known genetic contributor to meningioma formation was NF2, which is disrupted by mutation or loss in about 50% of tumors. Besides NF2, several recurrent driver mutations were recently uncovered through next-generation sequencing. Here, we performed whole-genome sequencing across 7 tumor-normal pairs to identify somatic genetic alterations in meningioma. As a result, Chromatin regulators, including multiple histone members, histone-modifying enzymes and several epigenetic regulators, are the major category among all of the identified copy number variants and single nucleotide variants. Notably, all samples contained copy number variants in histone members. Recurrent chromosomal rearrangements were detected on chromosome 22q, 6p21-p22 and 1q21, and most of the histone copy number variants occurred in these regions. These results will help to define the genetic landscape of meningioma and facilitate more effective genomics-guided personalized therapy.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 15043